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CaM Kinase 4/CaMKIV  蛋白

All CAMK4 Reagents

表达宿主: Baculovirus-Insect Cells  
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10664-H09B-20
10664-H09B-50
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50 µg 
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表达宿主: Baculovirus-Insect Cells  
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50838-M20B-20
50838-M20B-50
20 µg 
50 µg 
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表达宿主: Baculovirus-Insect Cells  
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50838-MNCB-20
50838-MNCB-50
20 µg 
50 µg 
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CaM Kinase 4/CaMKIV 相关信号通路

CaM Kinase 4/CaMKIV 相关蛋白、抗体、cDNA基因、ELISA试剂盒

CaM Kinase 4/CaMKIV 概述&蛋白信息

CaM Kinase 4/CaMKIV 研究背景

基因概述: The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
General information above from NCBI
催化活性: ATP + a protein = ADP + a phosphoprotein.
酶调控: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state.
亚单位结构: Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca(2+)/calmodulin.
结构域: The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
亚细胞定位: Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity).
组织特异性: Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
发育阶段: Expressed during differentiation of monocyte- derived dendritic cells (at protein level).
翻译后修饰: Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.
Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.
相似的序列: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.
General information above from UniProt

CaM Kinase 4/CaMKIV 别称

CAMK,IV,CaMKIV,CaMK-GR, [homo-sapiens]
caMK,CaMK IV,CaMK-GR,CAMK4,IV,MGC36771, [human]
A430110E23Rik,Camk4,CaMKIV,CaMKIV/Gr,AI666733,caMK IV,D18Bwg0362e, [mouse]
CaMKIV,AI666733,CaMKIV/Gr,D18Bwg0362e,A430110E23Rik, [mus-musculus]

CaM Kinase 4/CaMKIV 相关文献

  • Feliciano DM, et al. (2009) Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells. J Biol Chem. 284 (39): 26466-81.
  • Zhao X, et al. (2001). The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. J Biol Chem. 276 (37): 35042-8.
  • Racioppi L, et al. (2008) Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller.
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