FGF21 cDNA ORF Clone, Canine, C-DDK (Flag®) tag

Cat: DG70038-CF
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FGF21 cDNA ORF Clone, Canine, C-DDK (Flag®) tag 基本信息
基因
种属
Canine
NCBI 参考序列号
参考序列ORF长度
630 bp
描述
Full length Clone DNA of Canine fibroblast growth factor 21 with C terminal Flag tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-C-FLAG
标签序列
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

FGF21 Background Information

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.

Full Name
fibroblast growth factor 21
References
  • Zhang X, et al. (2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57(5): 1246-53.
  • Lundåsen T, et al. (2007) PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 360(2): 437-40.
  • Kharitonenkov A, et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-35.
  • FGF21 cDNA ORF Clone, Canine, Related Products

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    FGF21 cDNA ORF Clone in Cloning Vector, Canine DG70038-G
    FGF21 cDNA ORF Clone, Canine, untagged DG70038-UT
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    FGF21 cDNA ORF Clone, Canine, C-HA tag DG70038-CY
    FGF21 cDNA ORF Clone, Canine, N-HA tag DG70038-NY
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    FGF21 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    FGF21 cDNA ORF Clone in Cloning Vector, Mouse MG50421-M
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    FGF21 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50421-CF
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    FGF21 cDNA ORF Clone, Mouse, C-HA tag MG50421-CY
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    FGF21 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
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    FGF21 cDNA ORF Clone, Human, C-OFPSpark® tag HG10911-ACR
    FGF21 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10911-CF
    FGF21 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10911-NF
    FGF21 cDNA ORF Clone, Human, C-His tag HG10911-CH
    FGF21 cDNA ORF Clone, Human, N-His tag HG10911-NH
    FGF21 cDNA ORF Clone, Human, C-HA tag HG10911-CY
    FGF21 cDNA ORF Clone, Human, N-HA tag HG10911-NY
    FGF21 cDNA ORF Clone, Human, C-Myc tag HG10911-CM
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