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Cathepsin D / CTSD 抗体, 兔单抗

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Human CTSD 抗体产品信息
免疫原:Recombinant Human Cathepsin D / CTSD protein (Catalog#12517-H08H)
克隆号:010
Ig 类型:Rabbit IgG
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS with 5% trehalose
抗体制备方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human Cathepsin D / CTSD (rh Cathepsin D / CTSD; Catalog#12517-H08H; P07339; Met1-Leu412).
Human CTSD 抗体使用指导
特异性:Human Cathepsin D / CTSD
No cross-reactivity in ELISA with
Mouse CTSD
Human CTSA
Human CTSB
Human CTSL
Human BACE1
推荐应用:WB, IHC-P

WB: 2-10 μg/mL

IHC-P: 1-10 μg/mL

储存方法:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human CTSD 抗体WB实验图片
Human CTSD 抗体IHC实验图片
Cathepsin D / CTSD Antibody, Rabbit MAb, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of human CTSD in human cirrhosis with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections).
Cathepsin D / CTSD Antibody, Rabbit MAb, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of human CTSD in human cirrhosis with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections).
Cathepsin D / CTSD Antibody, Rabbit MAb, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of human CTSD in human lung cancer with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections).
Cathepsin D / CTSD Antibody, Rabbit MAb, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of human CTSD in human lung cancer with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections).
Other CTSD 抗体 Products
Cathepsin D/CTSD 研究背景

Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.

Human Cathepsin D/CTSD 参考资料
  • Fusek M, et al. (2005) Dual role of cathepsin D: ligand and protease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 149(1): 43-50.
  • Minarowska A, et al. (2007) Regulatory role of cathepsin D in apoptosis. Folia Histochem Cytobiol. 45(3): 159-63.
  • Zaidi N, et al. (2008) Cathepsin D: a cellular roadmap. Biochem Biophys Res Commun. 376(1): 5-9.
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    货号: 12517-R010-50
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