Clusterin (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Clusterin reagents are produced in house and quality controlled, including 15 Clusterin Antibody, 67 Clusterin Gene, 1 Clusterin IP Kit, 2 Clusterin Lysate, 2 Clusterin Protein, 2 Clusterin qPCR. All Clusterin reagents are ready to use.

Clusterin Protein (2)

Clusterin Antibody (15)

Clusterin cDNA Clone (67)

NM_001831.2

克隆载体 cDNA 产品

In lentiviral vector

NM_013492.2

克隆载体 cDNA 产品

In lentiviral vector

XM_006252094.2

克隆载体 cDNA 产品

In lentiviral vector

BC061534.1

克隆载体 cDNA 产品

In lentiviral vector

XM_005562917.1

克隆载体 cDNA 产品

In lentiviral vector

NM_001003370.1

克隆载体 cDNA 产品

In lentiviral vector

Clusterin Lysate (2)

Clusterin 分子背景

Clusterin, also known as complement-associated protein SP-4, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Clusterin 参考文献

  • Silkensen JR, et al. (1994) The role of clusterin in tissue injury. Biochem Cell Biol. 72(11-12): 483-8.
  • Naik RR, et al. (2002) Biomimetic synthesis and patterning of silver nanoparticles. Nat Mater. 1(3): 169-72.
  • Djeu JY, et al. (2009) Clusterin and chemoresistance. Adv Cancer Res. 105: 77-92.