Factor H (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Factor H reagents are produced in house and quality controlled, including 10 Factor H Antibody, 1 Factor H ELISA, 41 Factor H Gene, 3 Factor H Lysate, 3 Factor H Protein, 2 Factor H qPCR. All Factor H reagents are ready to use.

Factor H Protein (3)

Factor H Antibody (10)

Factor H ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

Factor H cDNA Clone (41)

NM_000186.3

克隆载体 cDNA 产品

In lentiviral vector

NM_009888.3

克隆载体 cDNA 产品

In lentiviral vector

BC089845.1

克隆载体 cDNA 产品

In lentiviral vector

Factor H Lysate (3)

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Factor H 分子背景

Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), membranoproliferative glomuleronephritis type II or dense deposit disease, as well as the more frequent retinal disease age related macular degeneration (AMD). In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin.

Factor H 参考文献

  • Zipfel PF. (2001) Complement factor H: physiology and pathophysiology. Semin Thromb Hemost. 27(3): 191-9.
  • Zipfel PF, et al. (2008) The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci. Vaccine. 26 Suppl 8: I67-74.
  • Ferreira VP, et al. (2010) Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol. 47(13): 2187-97.
  • Donoso LA, et al. (2010) The role of complement Factor H in age-related macular degeneration: a review. Surv Ophthalmol. 55(3): 227-46.