Cyclin E (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Cyclin E reagents are produced in house and quality controlled, including 5 Cyclin E Antibody, 30 Cyclin E Gene, 4 Cyclin E Lysate, 4 Cyclin E Protein, 2 Cyclin E qPCR. All Cyclin E reagents are ready to use.

Cyclin E Protein (4)

Cyclin E Antibody (5)

Cyclin E cDNA Clone (30)

NM_001238.1

克隆载体 cDNA 产品

In lentiviral vector

NM_007633.2

克隆载体 cDNA 产品

In lentiviral vector

Cyclin E Lysate (4)

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Cyclin E 相关研究领域

Cyclin E 分子背景

Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that bind, activate, and provide substrate for its associated cyclin-dependent kinase2 (CDK2), whose activity is essential for cell cycle G1 / S transition. Over expression of this encoding gene has been found in many tumors, which results in chromosome instability and by extension, induce tumorigenesis. This protein was also found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. In general, cyclin E1, as an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression and is frequently overexpressed in cancer cells.

Cyclin E 参考文献

  • Honda R, et al. (2005) The structure of cyclin E1 / CDK2: implications for CDK2 activation and CDK2-independent roles. The EMBO Journal. 24: 452-63.
  • Geng Y, et al. (2007) Kinase-Independent Function of Cyclin E. 25(1): 127-39.