FGFR1 cDNA ORF Clone, Rhesus, C-HA tag

Cat: CG90075-CY

Contact us:

215-583-7898
order@sinobiological.com
Distributors

All FGFR1 Reagents

CRO Services

Product recommended


All FGFR1 Reagents

FGFR1 cDNA ORF Clone, Rhesus, C-HA tag 基本信息

基因

种属
Rhesus
NCBI 参考序列号
参考序列ORF长度
2196 bp
描述
Full length Clone DNA of Rhesus fibroblast growth factor receptor 1 with C terminal HA tag.

质粒

启动子
Enhanced CMV promoter
载体
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

FGFR1 Background Information

FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ,idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
fibroblast growth factor receptor 1
References
  • Schlessinger J, et al. (2000) Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell. 6(3):743-50.
  • Dodé C, et al. (2007) Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis. Hum Mutat. 28(1): 97-8.
  • Kim HG, et al. (2005) Hypogonadotropic hypogonadism and cleft lip and palate caused by a balanced translocation producing haploinsufficiency for FGFR1. J Med Genet. 42(8):666-72.
  • FGFR1 cDNA ORF Clone, Rhesus, Related Products

    Product Name Catalog#(PDF)
    FGFR1 cDNA ORF Clone in Cloning Vector, Rhesus CG90075-G
    FGFR1 cDNA ORF Clone, Rhesus, untagged CG90075-UT
    FGFR1 cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90075-ACG
    FGFR1 Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90075-ACGLN
    FGFR1 cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90075-ACR
    FGFR1 cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90075-CF
    FGFR1 cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90075-NF
    FGFR1 cDNA ORF Clone, Rhesus, C-His tag CG90075-CH
    FGFR1 cDNA ORF Clone, Rhesus, N-His tag CG90075-NH
    FGFR1 cDNA ORF Clone, Rhesus, N-HA tag CG90075-NY
    FGFR1 cDNA ORF Clone, Rhesus, C-Myc tag CG90075-CM
    FGFR1 cDNA ORF Clone, Rhesus, N-Myc tag CG90075-NM

    FGFR1 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    FGFR1 cDNA ORF Clone in Cloning Vector, Mouse MG50186-M
    FGFR1 cDNA ORF Clone, Mouse, untagged MG50186-UT
    FGFR1 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50186-ACG
    FGFR1 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50186-ACGLN
    FGFR1 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50186-ACR
    FGFR1 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50186-CF
    FGFR1 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50186-NF
    FGFR1 cDNA ORF Clone, Mouse, C-His tag MG50186-CH
    FGFR1 cDNA ORF Clone, Mouse, N-His tag MG50186-NH
    FGFR1 cDNA ORF Clone, Mouse, C-HA tag MG50186-CY
    FGFR1 cDNA ORF Clone, Mouse, N-HA tag MG50186-NY
    FGFR1 cDNA ORF Clone, Mouse, C-Myc tag MG50186-CM
    FGFR1 cDNA ORF Clone, Mouse, N-Myc tag MG50186-NM
    FGFR1 qPCR Primer Pairs, Mouse MP200216

    FGFR1 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    FGFR1 cDNA ORF Clone in Cloning Vector, Human HG10616-M
    FGFR1 cDNA ORF Clone, Human, untagged HG29773-UT
    FGFR1 cDNA ORF Clone, Human, untagged HG10616-UT
    FGFR1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10616-ACGLN
    FGFR1 cDNA ORF Clone, Human, C-GFPSpark® tag HG10616-ACG
    FGFR1 cDNA ORF Clone, Human, C-OFPSpark® tag HG10616-ACR
    FGFR1 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10616-CF
    FGFR1 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10616-NF
    FGFR1 cDNA ORF Clone, Human, C-His tag HG10616-CH
    FGFR1 cDNA ORF Clone, Human, N-His tag HG10616-NH
    FGFR1 cDNA ORF Clone, Human, C-HA tag HG10616-CY
    FGFR1 cDNA ORF Clone, Human, N-HA tag HG10616-NY
    FGFR1 cDNA ORF Clone, Human, C-Myc tag HG10616-CM
    FGFR1 cDNA ORF Clone, Human, N-Myc tag HG10616-NM
    FGFR1 qPCR Primer Pairs, Human HP100865
    info info
    添加购物车成功! 添加购物车失败!