DKK1 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All DKK1 reagents are produced in house and quality controlled, including 10 DKK1 Antibody, 1 DKK1 ELISA, 26 DKK1 Gene, 1 DKK1 IP Kit, 4 DKK1 Lysate, 4 DKK1 Protein, 1 DKK1 qPCR. All DKK1 reagents are ready to use.

DKK1 Protein (4)

DKK1 Antibody (10)

DKK1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

DKK1 cDNA Clone (26)


克隆载体 cDNA 产品

In lentiviral vector


In expression vector

DKK1 qPCR Primer (1)

DKK1 Lysate (4)

DKK1 分子背景

Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

DKK1 参考文献

  • Horwitz EM. (2004) Dkk-1-mediated expansion of adult stem cells. Trends Biotechnol. 22(8): 386-8.
  • Jiang T, et al. (2009) Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer. 19(7): 1177-81.