快速订购

DLL4/Delta-like 4  蛋白,抗体,试剂盒,cDNA克隆

描述: Active  
表达宿主: Human Cells  
  • Slide 1
10171-H08H-50
10171-H08H-100
50 µg 
100 µg 
Add to Cart
描述: Active  
表达宿主: Human Cells  
  • Slide 1
10171-H02H-50
10171-H02H-100
50 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
10171-HCCH-50
10171-HCCH-200
50 µg 
200 µg 
Add to Cart
描述: Active  
表达宿主: Human Cells  
  • Slide 1
50640-M08H-50
50640-M08H-100
50 µg 
100 µg 
Add to Cart

DLL4/Delta-like 4 相关研究领域

DLL4/Delta-like 4 相关信号通路

    DLL4/Delta-like 4 概述&蛋白信息

    DLL4/Delta-like 4 研究背景

    基因概述: This DLL4 gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    亚单位结构: Binds to Notch-1 and Notch-4. {ECO:0000250}.
    结构域: The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor.
    亚细胞定位: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
    组织特异性: Expressed in vascular endothelium.
    翻译后修饰: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. {ECO:0000250}.
    相似的序列: Contains 1 DSL domain. {ECO:0000255|PROSITE-ProRule:PRU00377}.; Contains 8 EGF-like domains. {ECO:0000255|PROSITE-ProRule:PRU00076}.
    General information above from UniProt

    Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent studies yield substantial insights into the role of DLL4 in angiogenesis. DLL4 is induced by vascular endothelial growth factor (VEGF) and acts downstream of VEGF as a 'brake' on VEGF-induced vessel growth, forming an autoregulatory negative feedback loop inactivating VEGF. DLL4 is downstream of VEGF signaling and its activation triggers a negative feedback that restrains the effects of VEGF. Attenuation of DLL4/Notch signaling results in chaotic vascular network with excessive branching and sprouting. DLL4 is widely distributed in tissues other than vessels including many malignancies. Furthermore, the molecule is internalized on binding its receptor and often transported to the nucleus. In pathological conditions, such as cancer, DLL4 is up-regulated strongly in the tumour vasculature. Blockade of DLL4-mediated Notch signaling strikingly increases nonproductive angiogenesis, but significantly inhibits tumor growth in preclinical mouse models. In preclinical studies, blocking of DLL4/Notch signaling is associated with a paradoxical increase in tumor vessel density, yet causes marked growth inhibition due to functionally defective vasculature. Thus, DLL4 blockade holds promise as an additional strategy for angiogenesis-based cancer therapy.

    DLL4/Delta-like 4 别称

    Delta-like 4, []
    hdelta2, [homo-sapiens]
    delta 4,delta ligand 4,DLL4,hdelta2,MGC126344, [human]
    Delta4,Dll4,RP23-46P4.8, [mouse]
    Delta4, [mus-musculus]

    DLL4/Delta-like 4 相关文献

  • Yan M, et al. (2007) Delta-like 4/Notch signaling and its therapeutic implications. Clin Cancer Res. 13(24): 7243-6.
  • Sainson RC, et al. (2007) Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis? Trends Mol Med. 13(9): 389-95.
  • Martinez JC, et al. (2009) Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues. Histopathology. 54(5): 598-606.
  • Li JL, et al. (2010) Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity. Future Oncol. 6(7): 1099-103.
  • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”