DLL4 (Protein|Antibody|cDNA Clone|ELISA Kit)

All DLL4 reagents are produced in house and quality controlled, including 10 DLL4 Antibody, 4 DLL4 ELISA, 27 DLL4 Gene, 5 DLL4 Lysate, 5 DLL4 Protein, 2 DLL4 qPCR. All DLL4 reagents are ready to use.

Recombinant DLL4 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His, C-cleavage.

DLL4 antibodies are validated with different applications, which are ELISA(Cap), ELISA, WB, ELISA(Det).

DLL4 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each DLL4 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

DLL4 ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.

DLL4 Protein (5)

Species

DLL4 Protein, Rhesus, Recombinant (His Tag)

90882-C08H

Expression host: HEK293 Cells

Rhesus DLL4 Protein 20996

DLL4 Protein, Mouse, Recombinant (His Tag)

50640-M08H

Expression host: HEK293 Cells

Mouse DLL4/Delta-like 4 Protein 11791

DLL4 Protein, Human, Recombinant (His Tag)

10171-H08H

Expression host: HEK293 Cells

Human DLL4/Delta-like 4 Protein 8483

DLL4 Protein, Human, Recombinant

10171-HCCH

Expression host: HEK293 Cells

Human DLL4/Delta-like 4 Protein 15517

DLL4 Protein, Human, Recombinant (Fc Tag)

10171-H02H

Expression host: HEK293 Cells

Human DLL4/Delta-like 4 Protein 8482
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DLL4 Antibody (10)

Application Clonality
Host

Anti-DLL4 Antibody

10171-RP01

Specificity: Human

Application: ELISA

Clonality: PAb

Anti-DLL4 Antibody

10171-RP02

Specificity: Human

Application: ELISA

Clonality: PAb

Anti-DLL4 Antibody

10171-MM15

Specificity: Human

Application: ELISA

Clonality: MAb

Anti-DLL4 Antibody

50640-R004

Specificity: Mouse

Application: ELISA(Cap)

Clonality: MAb

Anti-DLL4 Antibody

50640-T16

Application: ELISA

Clonality: PAb

Anti-DLL4 Antibody

10171-MM06

Specificity: Human

Application: ELISA,ELISA(Cap)

Clonality: MAb

Anti-DLL4 Antibody

10171-R003

Specificity: Human

Application: ELISA,ELISA(Det)

Clonality: MAb

Anti-DLL4 Antibody

50640-R006

Specificity: Mouse

Application: ELISA

Clonality: MAb

Anti-DLL4 Antibody

50640-RP01

Specificity: Mouse

Application: ELISA

Clonality: PAb

Anti-DLL4 Antibody

50640-RP02

Specificity: Mouse

Application: ELISA

Clonality: PAb

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DLL4 ELISA KIT & match antibody elias pair set ( 4 )

DLL4 Matched ELISA Antibody Pair Set,Human

SEK10171

Assay Range: 31.25 pg/ml

Human DLL4/Delta-like 4 ELISA Pair Set Standard Curve 13800

DLL4 Matched ELISA Antibody Pair Set,Mouse

SEK50640

Assay Range: 9.375 pg/ml

Mouse DLL4/Delta-like 4 ELISA Pair Set Standard Curve 14009

DLL4 ELISA Kit, Mouse

KIT50640

Sensitivity: 11.9 pg/mL

Mouse DLL4/Delta-like 4 ELISA Kit Standard Curve 135

DLL4 ELISA Kit, Human

KIT10171

Sensitivity: 25.24 pg/mL

Human DLL4/Delta-like 4 ELISA Kit Standard Curve 43

DLL4 cDNA Clone (27)

Cynomolgus
Mouse
Human

DLL4 qPCR Primer (2)

DLL4 Lysate (5)

Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent studies yield substantial insights into the role of DLL4 in angiogenesis. DLL4 is induced by vascular endothelial growth factor (VEGF) and acts downstream of VEGF as a 'brake' on VEGF-induced vessel growth, forming an autoregulatory negative feedback loop inactivating VEGF. DLL4 is downstream of VEGF signaling and its activation triggers a negative feedback that restrains the effects of VEGF. Attenuation of DLL4/Notch signaling results in chaotic vascular network with excessive branching and sprouting. DLL4 is widely distributed in tissues other than vessels including many malignancies. Furthermore, the molecule is internalized on binding its receptor and often transported to the nucleus. In pathological conditions, such as cancer, DLL4 is up-regulated strongly in the tumour vasculature. Blockade of DLL4-mediated Notch signaling strikingly increases nonproductive angiogenesis, but significantly inhibits tumor growth in preclinical mouse models. In preclinical studies, blocking of DLL4/Notch signaling is associated with a paradoxical increase in tumor vessel density, yet causes marked growth inhibition due to functionally defective vasculature. Thus, DLL4 blockade holds promise as an additional strategy for angiogenesis-based cancer therapy.
Protein
Antibody
ELISA
Gene
qPCR
Lysate
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