Desmoglein-2 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Desmoglein-2 reagents are produced in house and quality controlled, including 26 Desmoglein-2 Gene, 1 Desmoglein-2 qPCR. All Desmoglein-2 reagents are ready to use.

Desmoglein-2 分子背景

Desmoglein-2 (Dsg2) is a specific cadherin of the cell-cell contact in cardiac desmosomes. Mutations in the DSG2-gene are regarded to cause arrhythmogenic (right ventricular) cardiomyopathy (ARVC) which is a rare but severe heart muscle disease. The depletion of DSG2 markedly decreased hPSC proliferation and pluripotency marker expression. In addition, DSG2-negative population in hPSCs exhibited a notable suppression in embryonic body and teratoma formation. The actions of DSG2 in regulating the self-renewal and pluripotency of hPSCs were predominantly exerted through the regulation of beta-catenin/Slug-mediated epithelial-to-mesenchymal transition. Which demonstrate that DSG2 is a valuable PSC surface marker that is essential for the maintenance of PSC self-renewal.