快速订购

E-Cadherin/CDH1/E-cad/CD324  蛋白,抗体,试剂盒,cDNA克隆

描述: Active  
表达宿主: Human Cells  
  • Slide 1
10204-H08H-200
10204-H08H-100
200 µg 
100 µg 
Add to Cart
表达宿主: Baculovirus-Insect Cells  
  • Slide 1
10204-H08B-20
10204-H08B-100
20 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
10204-H02H-50
10204-H02H-100
50 µg 
100 µg 
Add to Cart
描述: Active  
表达宿主: Human Cells  
  • Slide 1
50671-M08H-50
50671-M08H-100
50 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
80274-R02H-50
80274-R02H-100
50 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
80274-R08H-50
80274-R08H-100
50 µg 
100 µg 
Add to Cart

E-Cadherin/CDH1/E-cad/CD324 相关研究领域

E-Cadherin/CDH1/E-cad/CD324 相关信号通路

E-Cadherin/CDH1/E-cad/CD324 概述&蛋白信息

E-Cadherin/CDH1/E-cad/CD324 研究背景

基因概述: This CDH1 gene is a classical cadherin from the cadherin superfamily. E-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this CDH1 gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of E-cadherin mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
General information above from NCBI
亚单位结构: Homodimer; disulfide-linked. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Interacts with AJAP1, CTNND1 and DLGAP5 (By similarity). Interacts with TBC1D2. Interacts with LIMA1. Interacts with CAV1. Interacts with the TRPV4 and CTNNB1 complex (By similarity). Interacts with PIP5K1C. Interacts with RAB8B (By similarity). Interacts with RAPGEF2 (By similarity). Interacts with DDR1; this stabilizes CDH1 at the cell surface and inhibits its internalization. {ECO:0000250, ECO:0000269|PubMed:11226248, ECO:0000269|PubMed:12526809, ECO:0000269|PubMed:14595118, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:16126725, ECO:0000269|PubMed:17261850, ECO:0000269|PubMed:18093941, ECO:0000269|PubMed:19604491, ECO:0000269|PubMed:20116244, ECO:0000269|PubMed:20432435, ECO:0000269|PubMed:7982500}.
结构域: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000269|PubMed:2349235}.
亚细胞定位: Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
组织特异性: Non-neural epithelial tissues.
诱导: Expression is repressed by MACROD1. {ECO:0000269|PubMed:17893710}.
翻译后修饰: During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm. The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway. Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system. The gamma-secretase-mediated cleavage promotes disassembly of adherens junctions. {ECO:0000269|PubMed:10597309, ECO:0000269|PubMed:11076937, ECO:0000269|PubMed:11953314}.; N-glycosylation at Asn-637 is essential for expression, folding and trafficking. {ECO:0000269|PubMed:18491227}.; Ubiquitinated by a SCF complex containing SKP2, which requires prior phosphorylation by CK1/CSNK1A1. Ubiquitinated by CBLL1/HAKAI, requires prior phosphorylation at Tyr-754. {ECO:0000269|PubMed:21283129, ECO:0000269|PubMed:22252131, ECO:0000269|PubMed:22770219}.
相关疾病 : DISEASE: Hereditary diffuse gastric cancer (HDGC) [MIM:137215]: A cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. {ECO:0000269|PubMed:10319582, ECO:0000269|PubMed:12216071}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Heterozygous CDH1 germline mutations are responsible for familial cases of diffuse gastric cancer. Somatic mutations has also been found in patients with sporadic diffuse gastric cancer and lobular breast cancer.; DISEASE: Endometrial cancer (ENDMC) [MIM:608089]: A malignancy of endometrium, the mucous lining of the uterus. Most endometrial cancers are adenocarcinomas, cancers that begin in cells that make and release mucus and other fluids. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; DISEASE: Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO:0000269|PubMed:8075649}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; DISEASE: Breast cancer, lobular (LBC) [MIM:137215]: A type of breast cancer that begins in the milk-producing glands (lobules) of the breast. {ECO:0000269|PubMed:17660459}. Note=The gene represented in this entry may be involved in disease pathogenesis.
相似的序列: Contains 5 cadherin domains. {ECO:0000255|PROSITE-ProRule:PRU00043}.
General information above from UniProt

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.

E-Cadherin/CDH1/E-cad/CD324 别称

E-cad,ARC-1,E-cad, []
UVO,CDHE,ECAD,LCAM,Arc-1,CD324, [homo-sapiens]
Arc-1,CD324,CDH1,CDHE,ECAD,E-Cadherin,LCAM,UVO, [human]
AA960649,Cdh1,Ecad,E-Cadherin,L-CAM,MGC107495,Um,UVO, [mouse]
Um,UVO,Ecad,E-cad,L-CAM,AA960649, [mus-musculus]

E-Cadherin/CDH1/E-cad/CD324 相关文献

  • Wang HD, et al. (2004) CDH1 germline mutation in hereditary gastric carcinoma. World J Gastroenterol. 10(21): 3088-93.
  • Masterson J, et al. (2007) Posttranslational truncation of E-cadherin and significance for tumour progression. Cells Tissues Organs. 185(1-3): 175-9.
  • Mrgineanu E, et al. (2008) Correlation between E-cadherin abnormal expressions in different types of cancer and the process of metastasis. Rev Med Chir Soc Med Nat Iasi. 112(2): 432-6.
  • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”