输入关键词搜索之后,可以在左侧选择分子或者产品类型以精简过滤器,快速查找产品。如果有任何问题,请 联系我们!

快速订购

Text Size:AAA

E-Cadherin / CDH1 / E-cad / CD324 抗体, 兔单抗

产品数据评论相关产品实验方法
Human CDH1 抗体产品信息
免疫原:Recombinant Human E-cadherin / CDH1 / Cadherin-1 / E-Cad protein (Catalog#10204-H08H)
克隆号:032
Ig 类型:Rabbit IgG
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS with 5% trehalose
抗体制备方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human E-cadherin / CDH1 / Cadherin-1 / E-Cad (rh E-cadherin / CDH1 / Cadherin-1 / E-Cad; Catalog#10204-H08H; NP_004351.1; Met1-Ile707).
Human CDH1 抗体使用指导
特异性:Human E-cadherin / CDH1 / Cadherin-1 / E-Cad
Has cross-reactivity in ELISA with
Human CDH2
Human CDH5
Human Cad8
Human CDH17
Mouse CDH1
推荐应用:IHC-P

IHC-P: 1-10 μg/mL

储存方法:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human CDH1 抗体IHC实验图片
E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of human E-cadherin in human gastric cancer with rabbit monoclonal Antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of epithelial cells.
E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of human E-cadherin in human skin with rabbit monoclonal Antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of epithelial cells.
Other CDH1 抗体 Products
E-Cadherin/CDH1/E-cad/CD324 研究背景

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.

Human E-Cadherin/CDH1/E-cad/CD324 参考资料
  • Wang HD, et al. (2004) CDH1 germline mutation in hereditary gastric carcinoma. World J Gastroenterol. 10(21): 3088-93.
  • Masterson J, et al. (2007) Posttranslational truncation of E-cadherin and significance for tumour progression. Cells Tissues Organs. 185(1-3): 175-9.
  • Mrgineanu E, et al. (2008) Correlation between E-cadherin abnormal expressions in different types of cancer and the process of metastasis. Rev Med Chir Soc Med Nat Iasi. 112(2): 432-6.
  • Product nameProduct name
    Size / Price
    货号: 10204-R032-50
    目录价: 
    单价:      (You Save: )
    Contact Us
    产品图片
    • E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
    • E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
      您曾浏览过的产品
        产品数据可能随批次变化,最新数据请详见随货说明书。
        请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”