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Epidermal Growth Factor/EGF  蛋白,抗体,试剂盒,cDNA克隆

描述: Active  
表达宿主: Human Cells  
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10605-H01H-500
10605-H01H-100
10605-H01H-1
500 µg 
100 µg 
1 mg 
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表达宿主: E. coli  
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10605-HNAE-500
10605-HNAE-100
10605-HNAE-1
500 µg 
100 µg 
1 mg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
50482-M01H-500
50482-M01H-100
50482-M01H-1
500 µg 
100 µg 
1 mg 
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表达宿主: Human Cells  
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50482-M08H1-50
50482-M08H1-20
50 µg 
20 µg 
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描述: Active  
表达宿主: Yeast  
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50482-MNAY-500
50482-MNAY-100
50482-MNAY-1
500 µg 
100 µg 
1 mg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
50482-MNCH-500
50482-MNCH-100
50482-MNCH-1
500 µg 
100 µg 
1 mg 
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表达宿主: E. coli  
  • Slide 1
80446-RNAE-500
80446-RNAE-100
80446-RNAE-1
500 µg 
100 µg 
1 mg 
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描述: Active  
表达宿主: E. coli  
  • Slide 1
70013-D07E-500
70013-D07E-100
70013-D07E-1
500 µg 
100 µg 
1 mg 
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Epidermal Growth Factor/EGF 相关研究领域

Epidermal Growth Factor/EGF 相关信号通路

Epidermal Growth Factor/EGF 相关蛋白、抗体、cDNA基因、ELISA试剂盒

Epidermal Growth Factor/EGF 概述&蛋白信息

Epidermal Growth Factor/EGF 研究背景

基因概述: This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
General information above from NCBI
亚单位结构: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). {ECO:0000250, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21029725, ECO:0000269|PubMed:21439629}.
亚细胞定位: Membrane; Single-pass type I membrane protein.
组织特异性: Expressed in kidney, salivary gland, cerebrum and prostate. {ECO:0000269|PubMed:17671655}.
翻译后修饰: O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor). {ECO:0000269|PubMed:22171320}.
相关疾病 : DISEASE: Hypomagnesemia 4 (HOMG4) [MIM:611718]: A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. {ECO:0000269|PubMed:17671655}. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似的序列: Contains 9 EGF-like domains. {ECO:0000255|PROSITE-ProRule:PRU00076}.; Contains 9 LDL-receptor class B repeats. {ECO:0000255|PROSITE-ProRule:PRU00461}.
General information above from UniProt

EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. Human EGF is a 6045-Da protein with 53 amino acid residues and three intramolecular disulfide bonds. As a low-molecular-weight polypeptide, EGF was first purified from the mouse submandibular gland, but since then it was found in many human tissues including submandibular gland, parotid gland. It can also be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. Salivary EGF, which seems also regulated by dietary inorganic iodine, also plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. EGF acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation.

Epidermal Growth Factor/EGF 别称

Epidermal Growth Factor, []
URG,HOMG4, [homo-sapiens]
EGF,HOMG4,URG, [human]
AI790464,Egf, [mouse]
AI790464, [mus-musculus]

Epidermal Growth Factor/EGF 相关文献

  • Chen JX, et al. (2011) Involvement of c-Src/STAT3 signal in EGF-induced proliferation of rat spermatogonial stem cells. Mol Cell Biochem. 358(1-2):67-73.
  • Guo Y, et al. (2012) Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer. Oncol Rep. 27(1):286-92.
  • Kim S, et al. (2012) Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells. Cancer Lett. 314(2):147-54.
  • Chatterton RT Jr, et al. (2010) Breast ductal lavage for assessment of breast cancer biomarkers. Horm Cancer. 1(4):197-204.
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