Anti-EGFR Antibody

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Anti-EGFR Antibody (Rabbit Polyclonal 抗体) 产品信息

产品名称
Anti-EGFR Antibody
经验证的应用
ELISA
交叉反应
Reacts with: Mouse
特异性
Mouse EGFR
免疫原
Recombinant Mouse EGFR / HER1 / ErbB1 protein (Catalog#51091-M08H)
制备方法
Produced in rabbits immunized with purified, recombinant Mouse EGFR / HER1 / ErbB1 (Catalog#51091-M08H; Q01279; Met1-Ser647). Total IgG was purified by Protein A affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-EGFR Antibody (Rabbit Polyclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-EGFR Antibody: 别称

Anti-9030024J15Rik Antibody; Anti-AI552599 Antibody; Anti-Erbb Antibody; Anti-Errb1 Antibody; Anti-Errp Antibody; Anti-wa-2 Antibody; Anti-wa2 Antibody; Anti-Wa5 Antibody

EGFR 背景信息

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
全称
epidermal growth factor receptor
参考文献
  • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
  • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
  • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.
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