EphA1 cDNA ORF Clone in Cloning Vector, Human

Cat: HG15789-G
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EphA1 cDNA ORF Clone in Cloning Vector, Human 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
2931 bp
序列描述
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 479 T/C, 2698 A/G resulting in the amino acid Val substitution by Ala, Met substitution by Val and 1837 C/T, 2742 A/G not causing the amino acid variation.
描述
Full length Clone DNA of Human EPH receptor A1.
质粒
载体
pGEM-T Vector
测序引物
SP6 and T7 or M13-47 and RV-M
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Ampicillin
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.
EphA1 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

EphA1 cDNA ORF Clone in Cloning Vector, Human Alternative Names
EPH cDNA ORF Clone, Human;EPHT cDNA ORF Clone, Human;EPHT1 cDNA ORF Clone, Human
EphA1 Background Information

EPHA1 or EPH receptor A1 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. An important role of Eph receptors and their ligands ephrins is to mediate cell-contact-dependent repulsion. Eph receptors and ephrins also act at boundaries to channel neuronal growth cones along specific pathways, restrict the migration of neural crest cells, and via bidirectional signaling prevent intermingling between hindbrain segments. Eph receptors and ephrins can also trigger an adhesive response of endothelial cells and are required for the remodeling of blood vessels. Eph receptors and ephrins have emerged as key regulators of the repulsion and adhesion of cells that underlie the establishment, maintainence, and remodeling of patterns of cellular organization. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps.

Full Name
EPH receptor A1
References
  • Flanagan JG, et al. (1998) THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT. Annual Review of Neuroscience. 21: 309-45.
  • Wilkinson DG (2000) Eph receptors and ephrins: Regulators of guidance and assembly. International Review of Cytology. 196: 177-244.
  • Zhou R. (1998) The Eph family receptors and ligands. Pharmacol. 77 (3): 151-81.
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