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EPHA3/Eph Receptor A3  蛋白,抗体,试剂盒,cDNA克隆

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11459-H08H-50
11459-H08H-100
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51122-MNCB-50
51122-MNCB-20
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表达宿主: Human Cells  
51122-M08H-200
51122-M08H-100
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表达宿主: Baculovirus-Insect Cells  
51122-M20B-50
51122-M20B-20
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表达宿主: Human Cells  
51122-M02H-500
51122-M02H-200
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表达宿主: Human Cells  
80465-R02H-500
80465-R02H-200
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表达宿主: Human Cells  
80465-R08H-500
80465-R08H-200
500 µg 
200 µg 
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表达宿主: Human Cells  
80155-R02H-50
80155-R02H-200
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EPHA3/Eph Receptor A3 相关研究领域

EPHA3/Eph Receptor A3 相关信号通路

EPHA3/Eph Receptor A3 相关蛋白、抗体、cDNA基因、ELISA试剂盒

EPHA3/Eph Receptor A3 概述&蛋白信息

EPHA3/Eph Receptor A3 研究背景

基因概述: EPHA3 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA3 encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
General information above from NCBI
催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
亚单位结构: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3 signaling (By similarity). Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase activation. {ECO:0000250, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:14660665, ECO:0000269|PubMed:16239146, ECO:0000269|PubMed:18547520, ECO:0000269|PubMed:21135139}.
亚细胞定位: Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
组织特异性: Widely expressed. Highest level in placenta.
翻译后修饰: Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1. {ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:18547520, ECO:0000269|PubMed:21135139}.
相关疾病 : DISEASE: Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene represented in this entry may be involved in disease pathogenesis.
相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
General information above from UniProt

EPHA3 gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA3 gene encodes a protein that binds ephrin-A ligands. EPHA3 is involved in the retinotectal mapping of neurons. It may also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

EPHA3/Eph Receptor A3 别称

EK4,HEK,ETK1,HEK4,TYRO4,ETK, [homo-sapiens]
EK4,EPH receptor A3,EPHA3,EPH-like kinase 4,eph-like tyrosine kinase 1,ephrin type-A receptor 3,ETK,ETK1,HEK,HEK4,human embryo kinase 1,TYRO4,TYRO4 protein tyrosine kinase,tyrosine-protein kinase receptor ETK1, [human]
MEK4,ETK1,AW492086,Cek4,EK4,End3,Eph receptor A3,Epha3,EPH-like kinase 4,ephrin type-A receptor 3,Hek,Hek4,Tyro4,tyrosine-protein kinase receptor ETK1,tyrosine-protein kinase TYRO4, [mouse]
Hek,Cek4,ETK1,End3,Hek4,Mek4,Tyro4,AW492086, [mus-musculus]

EPHA3/Eph Receptor A3 相关文献

  • Holder N, et al. (1999) Eph receptors and ephrins: effectors of morphogenesis. Development. 126(10):2033-44.
  • Wilkinson DG. (2000) Eph receptors and ephrins: regulators of guidance and assembly. Int Rev Cytol. 196:177-244.
  • Xu Q, et al. (2001) Roles of Eph receptors and ephrins in segmental patterning. Philos Trans R Soc Lond B Biol Sci. 355(1399):993-1002.
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