EphA3 Protein, Mouse, Recombinant (aa 569-984)

Cat: 51122-MNCB
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EphA3 Protein, Mouse, Recombinant (aa 569-984) 产品信息
Purity
> 85 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Kinase activity untested
Protein Construction
A DNA sequence encoding the mouse EPHA3 (EDK98238.1) (Gly569-Val984) was expressed with two additional amino acids (Gly & Pro ) at the N-terminus.
Accession#
Expressed Host
Baculovirus-Insect cells
Species
Mouse
Predicted N Terminal
Gly
Molecule Mass
The recombinant mouse EPHA3 consists of 418 amino acids and has a calculated molecular mass of 46.6 kDa. The recombinant protein migrates as an approximately 44 kDa band in SDS-PAGE under reducing conditions.
Formulation
Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.0.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
EphA3 Protein, Mouse, Recombinant (aa 569-984) in SDS-PAGE
Mouse EPHA3/Eph Receptor A3 Protein 12098
EphA3 Protein, Mouse, Recombinant (aa 569-984) Alternative Names
AW492086 Protein, Mouse;Cek4 Protein, Mouse;End3 Protein, Mouse;ETK1 Protein, Mouse;Hek Protein, Mouse;Hek4 Protein, Mouse;Mek4 Protein, Mouse;Tyro4 Protein, Mouse
EphA3 Background Information

EPHA3 gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA3 gene encodes a protein that binds ephrin-A ligands. EPHA3 is involved in the retinotectal mapping of neurons. It may also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
EPH receptor A3
References
  • Holder N, et al. (1999) Eph receptors and ephrins: effectors of morphogenesis. Development. 126(10):2033-44.
  • Wilkinson DG. (2000) Eph receptors and ephrins: regulators of guidance and assembly. Int Rev Cytol. 196:177-244.
  • Xu Q, et al. (2001) Roles of Eph receptors and ephrins in segmental patterning. Philos Trans R Soc Lond B Biol Sci. 355(1399):993-1002.
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