Anti-EphB2 Antibody

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Anti-EphB2 Antibody (Rabbit Polyclonal 抗体) 产品信息

产品名称
Anti-EphB2 Antibody
经验证的应用
IHC-P
交叉反应
Reacts with: Human
特异性
Human EphB2
免疫原
A synthetic peptide corresponding to the N-terminus of the human EPHB2.
制备方法
Produced in rabbits immunized with A synthetic peptide corresponding to the N-terminus of the human EPHB2., and purified by antigen affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-EphB2 Antibody (Rabbit Polyclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-EphB2 Antibody (Rabbit Polyclonal 抗体) 图片

Immunochemical staining of human EPHB2 in human skeletal muscle with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).
Immunochemical staining of human EPHB2 in human placenta with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).
Immunochemical staining of human EPHB2 in human pancreas with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).

Anti-EphB2 Antibody: 别称

Anti-CAPB Antibody; Anti-DRT Antibody; Anti-EK5 Antibody; Anti-EPHT3 Antibody; Anti-ERK Antibody; Anti-Hek5 Antibody; Anti-PCBC Antibody; Anti-Tyro5 Antibody

EphB2 背景信息

Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA1, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.
全称
EPH receptor B2
参考文献
  • Zisch AH, et al. (1998) Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene. 16 (20): 2657-70.
  • Yu HH, et al. (2001) Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. Oncogene. 20 (30): 3995-4006.
  • Zisch AH, et al. (2000) Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. Oncogene. 19 (2): 177-87.
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