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Endoglin / CD105 抗体, 兔单抗

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Human ENG 抗体产品信息
免疫原:Recombinant Human Endoglin / CD105 protein (Catalog#10149-H08H)
克隆号:103
Ig 类型:Rabbit IgG
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS
抗体制备方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human Endoglin / CD105 (rh Endoglin / CD105 ; Catalog#10149-H08H; NP_001108225.1; Met1-Gly586).
Human ENG 抗体使用指导
特异性:Human Endoglin / CD105
推荐应用:ICC/IF, IF, FCM

FCM: 0.5-2 μg/Test

ICC/IF: 10-25 μg/mL

储存方法:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human ENG 抗体IF实验图片
Endoglin / CD105 Antibody, Rabbit MAb, Immunofluorescence
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Caption:
Immunofluorescence staining of Human CD105 in MSC cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-Human CD105 monoclonal antibody (15 µg/ml) at 37℃ 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cell membrane.
Human ENG 抗体FC实验图片
Endoglin / CD105  Antibody, Rabbit MAb, Flow cytometric analysis
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Caption:
Flow cytometric analysis of Human CD105 expression in HeLa cells.
Other ENG 抗体 Products
Endoglin/CD105  研究背景

Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

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货号: 10149-R103-100
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