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FSTL1 抗体, 兔单抗

  • FSTL1 Antibody, Rabbit MAb, Immunofluorescence
  • FSTL1 Antibody, Rabbit MAb
产品数据评论相关产品实验方法
 FSTL1 抗体产品信息
免疫原:Recombinant Human FSTL1 protein (Catalog#10924-H08H)
克隆号:009
Ig 类型:Rabbit IgG
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS
抗体制备方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human FSTL1 (rh FSTL1; Catalog#10924-H08H; NP_009016.1; Met1-Ile308).
 FSTL1 抗体IF实验图片
FSTL1 Antibody, Rabbit MAb, Immunofluorescence
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Caption:
Confocal immunofluorescence staining of Human FSTL1 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human FSTL1 monoclonal antibody (15 µg/ml) at 37℃ 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated goat Anti-rabbit IgG secondary antibody (green), countstained with DAPI (blue).Positive staining was localized to cytoplasm.
 FSTL1 抗体FC实验图片
FSTL1 Antibody, Rabbit MAb
[点击查看大图]
Caption:
Flow cytometric analysis of Human FSTL1 expression on HeLa cells . The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human FSTL1, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Other FSTL1 抗体 Products
FSTL1 研究背景

Follistatin-related protein 1 (FSTL1)  is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.

 FSTL1 参考资料
  • Rosenberg MI, et al. (2006) MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206. J Cell Biol. 175(1): 77-85.
  • Ouchi N, et al. (2010) DIP2A functions as a FSTL1 receptor. J Biol Chem. 285(10): 7127-34.
  • Geng Y, et al. (2011) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 108(17): 7058-63.
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    货号: 10924-R009-100
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    Datasheet & Documentation

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    请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”