FSTL1 Protein, Mouse, Recombinant (Fc Tag)

Cat: 51127-M02H

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FSTL1 Protein, Mouse, Recombinant (Fc Tag) 产品信息

Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the mouse FSTL1 (NP_032073.2) (Met1-Ile306) was expressed with the Fc region of human IgG1 at the C-terminus.
Accession#
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Glu 19
Molecule Mass
The recombinant mouse FSTL1 comprises 529 amino acids and has a predicted molecular mass of 59.5 kDa. The apparent molecular mass of the protein is approximately 69 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FSTL1 Protein, Mouse, Recombinant (Fc Tag) in SDS-PAGE

Mouse FSTL1 Protein 12105

FSTL1 Protein, Mouse, Recombinant (Fc Tag) Alternative Names

AI316791 Protein, Mouse;AW107808 Protein, Mouse;Fstl Protein, Mouse;TSC-36 Protein, Mouse

FSTL1 Background Information

Follistatin-related protein 1 (FSTL1)  is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.

Full Name
follistatin-like 1
References
  • Rosenberg MI, et al. (2006) MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206. J Cell Biol. 175(1): 77-85.
  • Ouchi N, et al. (2010) DIP2A functions as a FSTL1 receptor. J Biol Chem. 285(10): 7127-34.
  • Geng Y, et al. (2011) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 108(17): 7058-63.
  • Other FSTL1 Proteins

    Rat FSTL1 Proteins

    Product Name Cat.No.
    FSTL1 Protein, Rat, Recombinant (His Tag) 80885-H08H
    FSTL1 Protein, Rat, Recombinant (His Tag) 80885-R08H

    Mouse FSTL1 Proteins

    Product Name Cat.No.
    FSTL1 Protein, Mouse, Recombinant (His Tag) 51127-M08H

    Human FSTL1 Proteins

    Product Name Cat.No.
    FSTL1 Protein, Human, Recombinant (His Tag) 10924-H08H
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