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小鼠 FSTL1 蛋白 (Fc 标签)

产品数据评论相关产品实验方法
小鼠 FSTL1 蛋白产品信息
分子别称:AI316791,AW107808,Fstl,TSC-36
蛋白构建:A DNA sequence encoding the mouse FSTL1 (NP_032073.2) (Met1-Ile306) was expressed with the Fc region of human IgG1 at the C-terminus.
分子种属:Mouse
表达宿主:Human Cells
运输说明:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
小鼠 FSTL1 蛋白质控检测
纯度:> 95 % as determined by SDS-PAGE
内毒素:< 1.0 EU per μg of the protein as determined by the LAL method
稳定性:Samples are stable for up to twelve months from date of receipt at -70℃
预测N端:Glu 19
分子量:The recombinant mouse FSTL1 comprises 529 amino acids and has a predicted molecular mass of 59.5 kDa. The apparent molecular mass of the protein is approximately 69 kDa in SDS-PAGE under reducing conditions.
缓冲液:Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
小鼠 FSTL1 蛋白使用指导
储存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶条件:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
小鼠 FSTL1 蛋白SDS-PAGE
Mouse FSTL1 Protein (Fc Tag) SDS-PAGE

FSTL1 相关信号通路

Other FSTL1 蛋白 Products
FSTL1 研究背景

Follistatin-related protein 1 (FSTL1)  is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.

小鼠 FSTL1 参考资料
  • Rosenberg MI, et al. (2006) MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206. J Cell Biol. 175(1): 77-85.
  • Ouchi N, et al. (2010) DIP2A functions as a FSTL1 receptor. J Biol Chem. 285(10): 7127-34.
  • Geng Y, et al. (2011) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 108(17): 7058-63.
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    请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”