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雪貂 IFNG 基因全长ORF克隆 (表达载体), C端HA标签

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Ferret IFNG cDNA Clone产品信息
NCBI注册码:AB300566.1
参考序列ORF长度:501bp
cDNA基因描述:Full length Clone DNA of Ferret Interferon gamma with C terminal HA tag.
分子别称:IFNG
分子种属:Ferret
载体:pCMV3-C-HA
质粒:
限制性酶切位点:
Tag序列:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
序列信息:
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Kanamycin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Product nameProduct name
重组小鼠 IFNA2 / Interferon alpha 2 蛋白重组食蟹猴 IFNAR1 / IFNAR 蛋白重组食蟹猴 / 恒河猴 IFNA2 / Interferon alpha 2 蛋白重组人 IL29 / IFNL1 蛋白Cynomolgus IFNAR2 / IFNABR Protein (ECD, His Tag)Human IFNA4 Protein (His Tag)重组人 Interferon alpha 2 / IFNA2 蛋白重组小鼠 IL-28B / IFN-lambda-3 蛋白 (His 标签)Cynomolgus IFNA4 / IFNα4 / Interferon alpha-4 Protein (Fc Tag)重组食蟹猴 / 恒河猴 IFNG / Interferon Gamma 蛋白重组人 IFNα4 / IFNa4 / Interferon alpha-4 蛋白 (Fc 标签)重组人 IFNα4 / IFNa4 / Interferon alpha-4 蛋白 (His 标签)重组人 IFNGR1 / CD119 蛋白 (His & Fc 标签)重组人 IFNGR1 / CD119 蛋白 (His 标签)重组人 Interferon alpha 7 / IFNA7 蛋白 (Fc 标签)重组人 IFNA5 / IFNaG / Interferon alpha-G 蛋白 (Fc 标签)重组人 Interferon alpha-B / IFNA8 蛋白重组人 Interferon alpha 10 / IFNA10 蛋白 (Fc 标签)重组人 Interferon omega-1 / IFNω / IFNW1 蛋白 (Fc 标签)重组人 IFN omega 1 / IFNW1 蛋白 (His 标签)重组人 IFNAR2 / IFNABR 蛋白 (Fc 标签)重组人 IFNAR2 / IFNABR 蛋白 (His 标签)重组人 Interferon beta / IFN-beta / IFNB 蛋白 (Fc 标签)重组人 Interferon beta / IFN-beta / IFNB 蛋白Human IL-28B / IFN-lambda-3 Protein (His Tag)Human IFN-alpha / IFNA1 / IFN Protein (His Tag)重组人 Interferon alpha-B / IFNA8 蛋白 (His 标签)重组人 IFN-gamma / IFNG / γ-IFN 蛋白重组人 IFNL3 / IL28B / Interleukin-28B 蛋白 (His 标签)重组人 IL-29 / Interleukin-29 蛋白 (His 标签)重组小鼠 IFNA5 / IFNaG 蛋白 (His 标签)重组人 IFNAR1 / IFNAR 蛋白 (Fc 标签)重组人 IFNAR1 / IFNAR 蛋白 (His 标签)重组小鼠 IFNAR1 / IFNAR 蛋白 (His 标签)重组小鼠 IFNA2 / Interferon alpha 2 蛋白 (Fc 标签)重组小鼠 IFNA5 / IFNaG 蛋白 (Fc 标签)重组小鼠 IFNG / Interferon Gamma 蛋白重组小鼠 IFNGR2 蛋白 (His 标签)重组小鼠 IFNA14 / Interferon alpha-14 蛋白 (Fc 标签)重组小鼠 IFNA13 / Interferon alpha-13 蛋白 (Fc 标签)重组小鼠 IFNA4 / Interferon alpha-4 蛋白 (Fc 标签)重组小鼠 IFNGR1 / CD119 蛋白 (Fc 标签)重组小鼠 IFNGR1 / CD119 蛋白 (His 标签)重组小鼠 IFNB1 / IFN-beta / Interferon beta 蛋白 (Fc 标签)重组小鼠 IFNB1 / IFN-beta / Interferon beta 蛋白重组小鼠 IFNG / Interferon Gamma 蛋白 (Fc 标签)重组小鼠 IFNG / Interferon Gamma 蛋白 (His 标签)重组食蟹猴 / 恒河猴 IFNA14 / Interferon alpha-14 蛋白 (His 标签)重组雪貂 IFNG / Interferon Gamma 蛋白 (His 标签)重组大鼠 IFNA4 / IFNα4 / Interferon alpha-4 蛋白 (Fc 标签)重组大鼠 IFN-alpha / IFNA1 / IFN 蛋白 (Fc 标签)重组大鼠 IFN-alpha / IFNA1 / IFN 蛋白 (His 标签)重组大鼠 IFNGR / IFNGR1 蛋白 (Fc 标签)重组大鼠 IFNA5 / IFNaG 蛋白 (His 标签)重组大鼠 IFNG / Interferon Gamma 蛋白 (Fc 标签)重组食蟹猴 IFNA2 / Interferon alpha 2 蛋白 (Fc 标签)重组食蟹猴 IFNA2 / Interferon alpha 2 蛋白 (His 标签)重组食蟹猴 Interferon alpha-B / IFNA8 蛋白 (Fc 标签)重组食蟹猴 Interferon alpha-B / IFNA8 蛋白 (His 标签)重组食蟹猴 IFNA13 / Interferon alpha-13 蛋白 (Fc 标签)重组食蟹猴 IFNA13 / Interferon alpha-13 蛋白 (His 标签)重组食蟹猴 IFNAR1 / IFNAR 蛋白 (His 标签)重组食蟹猴 IFNA4 / IFNα4 / Interferon alpha-4 蛋白 (Fc 标签)重组食蟹猴 IFNGR / IFNGR1 蛋白 (Fc 标签)重组食蟹猴 IFNGR / IFNGR1 蛋白 (His 标签)重组食蟹猴 IFN gamma 蛋白 (His 标签)重组小鼠 IFNA14 / Interferon alpha-14 蛋白 (His 标签)重组食蟹猴 IFNB1 / IFN-beta / Interferon beta 蛋白 (Fc 标签)重组食蟹猴 IFNAR1 / IFNAR 蛋白 (Fc 标签)重组小鼠 IFNA13 / Interferon alpha-13 蛋白 (His 标签)重组小鼠 IFNA4 / IFNα4 / Interferon alpha-4 蛋白 (His 标签)
研究背景

IFN gamma, also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.

参考资料
  • Gray P W, et al. (1982) Structure of the human immune interferon gene. Nature. 298: 859-63.
  • Taya Y, et al. (1982) Cloning and structure of the human immune interferon-gamma chromosomal gene. EMBO J. 1: 953-8.
  • Goshima N, et al. (2008) Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nomura N Nat Methods. 5: 1011-7.
  • Thiel DJ, et al. (2000) Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. 8 (9): 927-36.
  • Naylor SL, et al. (1983) Human immune interferon gene is located on chromosome 12. J Exp Med. 157 (3): 1020-7.
  • Schoenborn JR, et al. (2007) Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol. 96: 41-101.
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    货号: FG60007-CY
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    库存2-3 weeks
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