Anti-GFAP Antibody

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Anti-GFAP Antibody (Rabbit Polyclonal 抗体) 产品信息

产品名称
Anti-GFAP Antibody
经验证的应用
IHC-P
交叉反应
Reacts with: Human
Predicted to React with: Rat (Species predicted to react based on 100% sequence homology)
特异性
Human GFAP
免疫原
A synthetic peptide corresponding to the C-terminus of the Human GFAP.
制备方法
Produced in rabbits immunized with purified, a synthetic peptide corresponding to the C-terminus of the Human GFAP, and purified by antigen affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-GFAP Antibody (Rabbit Polyclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-GFAP Antibody (Rabbit Polyclonal 抗体) 图片

Immunochemical staining of human GFAP in human glioma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human GFAP in human clear cell tumors (brain) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human GFAP in human brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-GFAP Antibody: 别称

Anti-ALXDRD Antibody

GFAP 背景信息

GFAP is a cell-specific marker which belongs to the intermediate filament family. It can distinguish astrocytes from other glial cells during development. GFAP is expressed in cells lacking fibronectin. It is a type III intermediate filaments protein which contains three domains: the head, rod and tail domains. GFAP functions in many important entral nervous system (CNS) processes, including cell communication and the functioning of the blood brain barrier. Improper GFAP regulation can cause multiple disorders. Defects in GFAP is related to Alexander disease which is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes.
全称
glial fibrillary acidic protein
参考文献
  • Buniatian G, et al., 1998, Biology of the cell. 90(1): 53-61.
  • Chen YS, et al., 2011, Experimental Cell Research. 317(16): 2252-66.
  • Isaacs A, et al., 1998, Genomics. 51(1): 152-4.
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