All GITR reagents are produced in house and quality controlled, including 4 GITR Antibody, 29 GITR Gene, 4 GITR Lysate, 6 GITR Protein, 2 GITR qPCR. All GITR reagents are ready to use.
Recombinant GITR proteins are expressed by HEK293 Cells, Human Cells, HEK293 with fusion tags as C-His, C-mouse IgG1-Fc, C-human IgG1-Fc.
GITRantibodies are validated with different applications, which are ELISA.
GITRcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each GITR of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.