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GM-CSF/CSF2  蛋白,抗体,试剂盒,cDNA克隆

描述: Active  
表达宿主: Human Cells  
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10015-H07H-500
10015-H07H-5
10015-H07H-20
10015-H07H-100
10015-H07H-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
10015-H01H-5
10015-H01H-20
10015-H01H-100
5 µg 
20 µg 
100 µg 
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表达宿主: Yeast  
  • Slide 1
10015-HNAY-500
10015-HNAY-5
10015-HNAY-20
10015-HNAY-100
10015-HNAY-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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表达宿主: Human Cells  
  • Slide 1
10015-HNAH-5
10015-HNAH-20
10015-HNAH-100
5 µg 
20 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
51048-MNAH-50
51048-MNAH-20
50 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
51048-M07H-50
51048-M07H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
51048-M01H-50
51048-M01H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
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80020-R07H-50
80020-R07H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
80020-R01H-50
80020-R01H-20
50 µg 
20 µg 
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GM-CSF/CSF2 相关研究领域

GM-CSF/CSF2 相关信号通路

    GM-CSF/CSF2 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    GM-CSF/CSF2 概述&蛋白信息

    GM-CSF/CSF2 研究背景

    基因概述: GM-CSF is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exit the circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. Thus, it is part of the immune/inflammatory cascade, by which activation of a small number of macrophages can rapidly lead to an increase in their numbers, a process crucial for fighting infection. The active form of the protein is found extracellularly as a homodimer.
    General information above from NCBI
    亚单位结构: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. {ECO:0000269|PubMed:18692472}.
    亚细胞定位: Secreted.
    相似的序列: Belongs to the GM-CSF family. {ECO:0000305}.
    General information above from UniProt

    Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also has been shown to induce the differentiation of myeloid dendritic cells (DCs) that promote the development of T-helper type 1 (cellular) immune responses in cognate T cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility.

    GM-CSF/CSF2 别称

    GM-CSF/CSF2 相关文献

  • Robertson SA. (2007) GM-CSF regulation of embryo development and pregnancy. Cytokine Growth Factor Rev. 18(3-4): 287-98.
  • Waller EK. (2007) The role of sargramostim (rhGM-CSF) as immunotherapy. Oncologist. 12 Suppl 2: 22-6.
  • Clive KS, et al. (2010) Use of GM-CSF as an adjuvant with cancer vaccines: beneficial or detrimental? Expert Rev Vaccines. 9(5): 519-25.
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