Anti-Her2 / ERBB2 Antibody

Price:
Size:
Number:

Anti-Her2 / ERBB2 Antibody (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-Her2 / ERBB2 Antibody
经验证的应用
ELISA
交叉反应
Reacts with: Rat
特异性
Rat Her2 / ERBB2
Has cross-reactivity in ELISA with
Mouse Erbb2
No cross-reactivity in ELISA with
Human Erbb2
Rat ERBB3
Rat ERBB4
Human EGFR
免疫原
Recombinant Rat HER2 / ErbB2 protein (Catalog#80079-R08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Rat HER2 / ErbB2 (Catalog#80079-R08H; AAH61863.1; Met4-Thr656).
来源
Monoclonal Rabbit IgG Clone #006
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Her2 / ERBB2 Antibody (Rabbit Monoclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Her2 / ERBB2 背景信息

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD34, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
全称
erb-b2 receptor tyrosine kinase 2
参考文献
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
添加购物车成功! 添加购物车失败!请再次尝试 正在更新购物车,请稍后