Her2 / ERBB2 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Her2 / ERBB2 reagents are produced in house and quality controlled, including 34 Her2 / ERBB2 Antibody, 2 Her2 / ERBB2 ELISA, 39 Her2 / ERBB2 Gene, 2 Her2 / ERBB2 IP Kit, 18 Her2 / ERBB2 Lysate, 21 Her2 / ERBB2 Protein, 3 Her2 / ERBB2 qPCR. All Her2 / ERBB2 reagents are ready to use.

All Her2 / ERBB2 Reagents

Her2 / ERBB2 Protein (21)

Her2 / ERBB2 Antibody (34)

Her2 / ERBB2 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

Her2 / ERBB2 cDNA Clone (39)

NM_004448.2

克隆载体 cDNA 产品

In lentiviral vector

NM_001003817.1

克隆载体 cDNA 产品

In lentiviral vector

BC061863.1

克隆载体 cDNA 产品

In lentiviral vector

Her2 / ERBB2 Lysate (18)

Her2 / ERBB2 分子背景

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD34, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Her2 / ERBB2 参考文献

  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.