Anti-HER3 / ERBB3 Antibody

Cat: 80111-T16

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All HER3 / ERBB3 Reagents

Anti-HER3 / ERBB3 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-HER3 / ERBB3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Rat
Specificity
Rat HER3 / ERBB3
Immunogen
Recombinant Rat HER3 / ErbB3 protein (Catalog#80111-R08H)
Preparation
Produced in rabbits immunized with purified, recombinant Rat HER3 / ErbB3 (Catalog#80111-R08H; Q3MHC0; Met1-His641). HER3 / ErbB3 specific IgG was purified by Rat HER3 / ErbB3 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-HER3 / ERBB3 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

HER3 / ERBB3 Background Information

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
erb-b2 receptor tyrosine kinase 3
References
  • Kraus M.H., et al.,(1989), Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197.
  • Plowman G.D., et al., (1990), Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909.
  • Katoh M., et al.,(1993), c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.Biochem. Biophys. Res. Commun. 192:1189-1197.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 90043-T16
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 90043-RP01
    Anti-HER3 / ERBB3 Antibody Mouse Monoclonal ELISA 90043-MM05
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 80111-RP01
    Anti-HER3 / ERBB3 Antibody Rabbit Monoclonal ELISA(Cap) 51003-R128
    Anti-HER3 / ERBB3 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 51003-R138
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 51003-T16
    Anti-HER3 / ERBB3 Antibody Rabbit Monoclonal ELISA 51003-R028
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 51003-RP01
    Anti-HER3 / ERBB3 Antibody (PE) Mouse Monoclonal FCM 10201-MM03-P
    HER3 / ErbB3 Neutralizing Antibody Mouse Monoclonal Neutralization 10201-mhA24
    HER3 / ErbB3 Neutralizing Antibody Mouse Monoclonal Neutralization 10201-MA24
    Anti-HER3 / ERBB3 Antibody Rabbit Monoclonal ELISA 10201-R016
    Anti-HER3 / ERBB3 Antibody Mouse Monoclonal ELISA 10201-MM01
    Anti-HER3 / ERBB3 Antibody (FITC) Mouse Monoclonal FCM 10201-MM03-F
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 10201-T16
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal WB,ELISA,IP 10201-RP02
    Anti-HER3 / ERBB3 Antibody (APC) Mouse Monoclonal FCM 10201-MM03-A
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA,IHC-P 10201-T24
    Anti-HER3 / ERBB3 Antibody Rabbit Polyclonal ELISA 10201-RP01
    Anti-HER3 / ERBB3 Antibody Rabbit Monoclonal ELISA(Det) 10201-R015
    HER3 / ErbB3 Neutralizing Antibody Mouse Monoclonal Neutralization 10201-M908
    HER3 / ErbB3 Neutralizing Antibody Mouse Monoclonal Neutralization 10201-mh908
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