All HER3 / ERBB3 reagents are produced in house and quality controlled, including 24 HER3 / ERBB3 Antibody, 4 HER3 / ERBB3 ELISA, 39 HER3 / ERBB3 Gene, 1 HER3 / ERBB3 IPKit, 12 HER3 / ERBB3 Lysate, 12 HER3 / ERBB3 Protein, 2 HER3 / ERBB3 qPCR. All HER3 / ERBB3 reagents are ready to use.
Recombinant HER3 / ERBB3 proteins are expressed by HEK293 Cells, Baculovirus-Insect Cells with fusion tags as C-human IgG1-Fc, C-His, C-cleavage, C-mouse IgG1-Fc, N-GST & His.
HER3 / ERBB3antibodies are validated with different applications, which are ELISA, FCM, Neutralization, ELISA(Det), ELISA(Cap), WB, IP, ICC/IF, IF, IHC-P.
HER3 / ERBB3cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each HER3 / ERBB3 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
HER3 / ERBB3ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Expression host: HEK293 Cells
Expression host: Baculovirus-Insect Cells
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.