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HVEM/TNFRSF14/CD270  蛋白,抗体,试剂盒,cDNA克隆

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10334-H03H-200
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10334-H08H-200
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10567-M03H-200
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90109-C02H-50
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HVEM/TNFRSF14/CD270 相关研究领域

HVEM/TNFRSF14/CD270 相关信号通路

HVEM/TNFRSF14/CD270 相关蛋白、抗体、cDNA基因、ELISA试剂盒

HVEM/TNFRSF14/CD270 概述&蛋白信息

HVEM/TNFRSF14/CD270 研究背景

基因概述: The protein encoded by TNFRSF14 gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. [provided by RefSeq, Jul 2008]
General information above from NCBI
亚单位结构: Interacts with TRAF2, TRAF3 and TRAF5. Interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 1 (HHV-2) envelope glycoprotein D; functions as an entry receptor for these viruses.
亚细胞定位: Membrane; Single-pass type I membrane protein (Probable).
组织特异性: Widely expressed, with the highest expression in lung, spleen and thymus.
翻译后修饰: N-glycosylated.
相似的序列: Contains 3 TNFR-Cys repeats.
General information above from UniProt

Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA). HVEM provides a stimulatory signal following engagement with LIGHT (TNFSF14) on T cells. In contrast, it can also provide an inhibitory signal to T cells when it binds the B and T lymphocyte attenuator (BTLA), a ligand member of the Immunoglobulin (Ig) superfamily. Thus, HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.

Immune Checkpoint
Immune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA Antibodies
Immune Checkpoint Proteins
Immune Checkpoint TargetsCo-inhibitory Immune Checkpoint Targets

HVEM/TNFRSF14/CD270 别称

TR2,ATAR,HVEA,HVEM,CD270,LIGHTR, [homo-sapiens]
ATAR,HVEA,HVEM,LIGHTR,RP3-395M20.6,TNFRSF14,TR2, [human]
Atar,HveA,Hvem,MGC123498,MGC123499,RP24-89N4.1,Tnfrs14,Tnfrsf14, [mouse]
Atar,HveA,Hvem,Tnfrs14, [mus-musculus]

HVEM/TNFRSF14/CD270 相关文献

  • Murphy KM, et al. (2006) Balancing co-stimulation and inhibition with BTLA and HVEM. Nat Rev Immunol. 6(9): 671-81.
  • Heo SK, et al. (2007) HVEM signaling in monocytes is mediated by intracellular calcium mobilization. J Immunol. 179(9): 6305-10.
  • Steinberg MW, et al. (2008) A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med. 205(6): 1463-76.
  • Pasero C, et al. (2009) A role for HVEM, but not lymphotoxin-beta receptor, in LIGHT-induced tumor cell death and chemokine production. Eur J Immunol. 39(9): 2502-14.
  • Cheung TC. Modulation of T cell proliferation through the LIGHT-HVEM-BTLA cosignaling pathway. Recent Pat DNA Gene Seq. 3(3): 177-82.
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