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人 ABL1 基因全长ORF克隆 (表达载体), 无标签

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Human ABL1 cDNA Clone产品信息
NCBI注册码:BC_117451.1
参考序列ORF长度:3450bp
cDNA基因描述:Full length Clone DNA of Homo sapiens c-abl oncogene 1, receptor tyrosine kinase.
分子别称:ABL, JTK7, p150, c-ABL, v-abl, bcr/abl,
分子种属:Human
载体:pCMV3-untagged
质粒:pCMV3-ABL1
限制性酶切位点:KpnI (two restriction sites) + XbaI (6.11kb+3.01kb+0.44kb)
Tag序列:
序列信息:Identical with the Gene Bank Ref. ID sequence except for the point mutations: 9 G>A, 12 G>A, 1554 A>G and 3381 A>G not causing the amino acid variation.
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Ampicilin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
Human ABL1 基因质粒图
Human ABL1 natural ORF mammalian expression plasmid
Product nameProduct name
研究背景

c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.

参考资料
  • Qiu Z, et al. (2010) c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci U S A. 107(3): 1136-41.
  • Huang Y, et al. (2008) The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse. Blood. 112(1): 111-9.
  • Sirvent A, et al. (2008) Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells. Biol Cell. 100(11): 617-31.
  • Shaul Y, et al. (2005) Role of c-Abl in the DNA damage stress response. Cell Res. 15(1): 33-5.
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    货号: HG11199-UT
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    • Human ABL1 natural ORF mammalian expression plasmid
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