( We provide with ADAM15 qPCR primers for gene expression analysis, HP100023 )
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|人 ADAM15 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||HG10517-ACG|
|人 ADAM15 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||HG10517-ACR|
|人 ADAM15 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||HG10517-CF|
|人 ADAM15 基因ORF全长cDNA克隆(表达载体), C-His 标签||HG10517-CH|
|人 ADAM15 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||HG10517-CM|
|人 ADAM15 基因ORF全长cDNA克隆(表达载体), C-HA 标签||HG10517-CY|
|人 ADAM15 基因ORF全长cDNA(克隆载体)||HG10517-M|
|人 ADAM15 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||HG10517-NF|
|人 ADAM15 基因ORF全长cDNA克隆(表达载体), N-His 标签||HG10517-NH|
|人 ADAM15 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||HG10517-NM|
|人 ADAM15 基因ORF全长cDNA克隆(表达载体), N-HA 标签||HG10517-NY|
|人 ADAM15 基因ORF全长cDNA克隆(表达载体)||HG10517-UT|
ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.