AIM2 cDNA ORF Clone, Human, C-DDK (Flag®) tag

Cat: HG11654-CF
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All AIM2 Reagents
CRO Services
Product recommended

All AIM2 Reagents
AIM2 cDNA ORF Clone, Human, C-DDK (Flag®) tag 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
1071 bp
序列描述
Identical with the Gene Bank Ref. ID sequence.
描述
Full length Clone DNA of Human absent in melanoma 2 with C terminal Flag tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-C-FLAG
限制性酶切位点
KpnI + XbaI(6kb+1.07kb)
标签序列
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.
AIM2 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

AIM2 cDNA ORF Clone, Human, C-DDK (Flag®) tag Validated Images
other Green fluorescent protein / GFP Gene Plasmid Map 5609
AIM2 cDNA ORF Clone, Human, C-DDK (Flag®) tag Alternative Names
PYHIN4 cDNA ORF Clone, Human
AIM2 Background Information

AIM2, Absent In Melanoma 2 is a member of the interferon-inducible HIN-200 protein family that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding domain, senses cytoplasmic DNA by means of its oligonucleotide/oligosaccharide-binding domain and interacts with ASC (apoptosis-associated speck-like protein containing a CARD) through its pyrin domain to activate caspase-1. In response to foreign cytoplasmic DNA, AIM2 forms an inflammasome, resulting in caspase activation in inflammatory cells. It had been pointed to a role of AIM2 function in both inflammation and cancer. AIM-2 antigen is expressed in a wide variety of tumor types, including neuroectodermal tumors, as well as breast, ovarian and colon carcinomas. AIM-2 could be used as a tumor antigen target for monitoring vaccine trials or to develop antigen specific active immunotherapy for glioma patients.

Full Name
absent in melanoma 2
References
  • Patsos G, et al. (2010) Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. Int J Cancer. 126(8): 1838-49.
  • Fernandes-Alnemri T, et al. (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 458(7237): 509-13.
  • Chen IF, et al. (2006) AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Mol Cancer Ther. 5(1): 1-7.
  • Liu G, et al. (2004) AIM-2: a novel tumor antigen is expressed and presented by human glioma cells. J Immunother. 27(3): 220-6.
  • AIM2 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    AIM2 cDNA ORF Clone in Cloning Vector, Mouse MG58612-G
    AIM2 cDNA ORF Clone, Mouse, untagged MG58612-UT
    AIM2 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG58612-ACG
    AIM2 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG58612-ACGLN
    AIM2 cDNA ORF Clone, Mouse, N-GFPSpark® tag MG58612-ANG
    AIM2 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG58612-ACR
    AIM2 cDNA ORF Clone, Mouse, N-OFPSpark® tag MG58612-ANR
    AIM2 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG58612-CF
    AIM2 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG58612-NF
    AIM2 cDNA ORF Clone, Mouse, C-His tag MG58612-CH
    AIM2 cDNA ORF Clone, Mouse, N-His tag MG58612-NH
    AIM2 cDNA ORF Clone, Mouse, C-HA tag MG58612-CY
    AIM2 cDNA ORF Clone, Mouse, N-HA tag MG58612-NY
    AIM2 cDNA ORF Clone, Mouse, C-Myc tag MG58612-CM
    AIM2 cDNA ORF Clone, Mouse, N-Myc tag MG58612-NM

    AIM2 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    AIM2 cDNA ORF Clone in Cloning Vector, Human HG11654-M
    AIM2 cDNA ORF Clone, Human, untagged HG11654-UT
    AIM2 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG11654-ACGLN
    AIM2 cDNA ORF Clone, Human, C-GFPSpark® tag HG11654-ACG
    AIM2 cDNA ORF Clone, Human, N-GFPSpark® tag HG11654-ANG
    AIM2 cDNA ORF Clone, Human, C-OFPSpark® tag HG11654-ACR
    AIM2 cDNA ORF Clone, Human, N-OFPSpark® tag HG11654-ANR
    AIM2 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG11654-NF
    AIM2 cDNA ORF Clone, Human, C-His tag HG11654-CH
    AIM2 cDNA ORF Clone, Human, N-His tag HG11654-NH
    AIM2 cDNA ORF Clone, Human, C-HA tag HG11654-CY
    AIM2 cDNA ORF Clone, Human, N-HA tag HG11654-NY
    AIM2 cDNA ORF Clone, Human, C-Myc tag HG11654-CM
    AIM2 cDNA ORF Clone, Human, N-Myc tag HG11654-NM
    AIM2 qPCR Primer Pairs, Human HP101499
    info info
    添加购物车成功! 添加购物车失败!