ANGPTL4 cDNA ORF Clone, Human, N-DDK (Flag®) tag

Cat: HG10563-NF
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ANGPTL4 cDNA ORF Clone, Human, N-DDK (Flag®) tag 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
1233 bp
序列描述
Identical with the Gene Bank Ref. ID sequence.
描述
Full length Clone DNA of Human angiopoietin-like 4, transcript variant 1 with N terminal Flag tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-SP-N-FLAG
限制性酶切位点
KpnI + XbaI(6kb+1.23kb)
标签序列
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.
ANGPTL4 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ANGPTL4 cDNA ORF Clone, Human, N-DDK (Flag®) tag Validated Images
Rhesus CD64/Fc gamma RI Gene Plasmid Map 5614
ANGPTL4 cDNA ORF Clone, Human, N-DDK (Flag®) tag Alternative Names
ANGPTL2 cDNA ORF Clone, Human;ARP4 cDNA ORF Clone, Human;FIAF cDNA ORF Clone, Human;HARP cDNA ORF Clone, Human;HFARP cDNA ORF Clone, Human;NL2 cDNA ORF Clone, Human;PGAR cDNA ORF Clone, Human;pp1158 cDNA ORF Clone, Human;TGQTL cDNA ORF Clone, Human;UNQ171 cDNA ORF Clone, Human
ANGPTL4 Background Information

ANGPTL4, also known as ANGPTL2, is a protein with hypoxia-induced expression in endothelial cells. It contains 1 fibrinogen C-terminal domain and is expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may also exert a protective function on endothelial cells through an endocrine action. ANGPTL4 is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Full Name
angiopoietin-like 4
References
  • Lichtenstein L, et al. (2010) Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages. Cell metabolism. 12(6): 580-92.
  • Terada S, et al. (2011) Escaping Anoikis through ROS: ANGPTL4 controls integrin signaling through Nox1. Cancer Cell. 19(3):297-9.
  • Zhu PC, et al. (2011) Angptl4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors. Cancer Cell. 19(3):401-15.
  • ANGPTL4 cDNA ORF Clone, Cynomolgus, Related Products

    Product Name Catalog#(PDF)
    ANGPTL4 cDNA ORF Clone in Cloning Vector, Cynomolgus CG90529-U
    ANGPTL4 cDNA ORF Clone, Cynomolgus, untagged CG90529-UT
    ANGPTL4 cDNA ORF Clone, Cynomolgus, C-GFPSpark® tag CG90529-ACG
    ANGPTL4 Lentiviral cDNA ORF Clone, Cynomolgus, C-GFPSpark® tag CG90529-ACGLN
    ANGPTL4 cDNA ORF Clone, Cynomolgus, C-OFPSpark® tag CG90529-ACR
    ANGPTL4 cDNA ORF Clone, Cynomolgus, C-DDK (Flag®) tag CG90529-CF
    ANGPTL4 cDNA ORF Clone, Cynomolgus, N-DDK (Flag®) tag CG90529-NF
    ANGPTL4 cDNA ORF Clone, Cynomolgus, C-His tag CG90529-CH
    ANGPTL4 cDNA ORF Clone, Cynomolgus, N-His tag CG90529-NH
    ANGPTL4 cDNA ORF Clone, Cynomolgus, C-HA tag CG90529-CY
    ANGPTL4 cDNA ORF Clone, Cynomolgus, N-HA tag CG90529-NY
    ANGPTL4 cDNA ORF Clone, Cynomolgus, C-Myc tag CG90529-CM
    ANGPTL4 cDNA ORF Clone, Cynomolgus, N-Myc tag CG90529-NM

    ANGPTL4 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    ANGPTL4 cDNA ORF Clone in Cloning Vector, Mouse MG50356-M
    ANGPTL4 cDNA ORF Clone, Mouse, untagged MG50356-UT
    ANGPTL4 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50356-ACGLN
    ANGPTL4 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50356-ACG
    ANGPTL4 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50356-ACR
    ANGPTL4 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50356-CF
    ANGPTL4 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50356-NF
    ANGPTL4 cDNA ORF Clone, Mouse, C-His tag MG50356-CH
    ANGPTL4 cDNA ORF Clone, Mouse, N-His tag MG50356-NH
    ANGPTL4 cDNA ORF Clone, Mouse, C-HA tag MG50356-CY
    ANGPTL4 cDNA ORF Clone, Mouse, N-HA tag MG50356-NY
    ANGPTL4 cDNA ORF Clone, Mouse, C-Myc tag MG50356-CM
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    ANGPTL4 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    ANGPTL4 cDNA ORF Clone in Cloning Vector, Human HG10563-M
    ANGPTL4 cDNA ORF Clone, Human, untagged HG10563-UT
    ANGPTL4 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10563-ACGLN
    ANGPTL4 cDNA ORF Clone, Human, C-GFPSpark® tag HG10563-ACG
    ANGPTL4 cDNA ORF Clone, Human, C-OFPSpark® tag HG10563-ACR
    ANGPTL4 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10563-CF
    ANGPTL4 cDNA ORF Clone, Human, C-His tag HG10563-CH
    ANGPTL4 cDNA ORF Clone, Human, N-His tag HG10563-NH
    ANGPTL4 cDNA ORF Clone, Human, C-HA tag HG10563-CY
    ANGPTL4 cDNA ORF Clone, Human, N-HA tag HG10563-NY
    ANGPTL4 cDNA ORF Clone, Human, C-Myc tag HG10563-CM
    ANGPTL4 cDNA ORF Clone, Human, N-Myc tag HG10563-NM
    ANGPTL4 qPCR Primer Pairs, Human HP100574
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