B Raf cDNA ORF Clone, Human, C-Myc tag

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B Raf cDNA ORF Clone, Human, C-Myc tag: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
2301 bp
产品特征
Full length Clone DNA of Human v-raf murine sarcoma viral oncogene homolog B1 with C terminal Myc tag.
质粒
启动子
Enhanced CMV promoter
载体
标签序列
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

B Raf cDNA ORF Clone, Human, C-Myc tag: 别称

B-RAF1 cDNA ORF Clone, Human; BRAF1 cDNA ORF Clone, Human; NS7 cDNA ORF Clone, Human; RAFB1 cDNA ORF Clone, Human

B Raf 背景信息

BRAF gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. BRAFprotein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in BRAF gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in BRAF gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.
全称
B-Raf proto-oncogene, serine/threonine kinase
参考文献
  • Weston-Bell NJ, Tapper W, Gibson J, et al. Exome Sequencing in Classic Hairy Cell Leukaemia Reveals Widespread Variation in Acquired Somatic Mutations between Individual Tumours Apart from the Signature BRAF V(600)E Lesion. Richards KL, ed. PLoS ONE. 2016;11(2):e0149162. doi:10.1371/journal.pone.0149162.
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