MCP2 cDNA ORF Clone, Human, C-DDK (Flag®) tag

Cat: HG10989-CF
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All MCP2 Reagents
CRO Services
Product recommended

All MCP2 Reagents
MCP2 cDNA ORF Clone, Human, C-DDK (Flag®) tag 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
300 bp
描述
Full length Clone DNA of Human chemokine (C-C motif) ligand 8 with C terminal Flag tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-C-FLAG
标签序列
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

MCP2 cDNA ORF Clone, Human, C-DDK (Flag®) tag Alternative Names
HC14 cDNA ORF Clone, Human;MCP-2 cDNA ORF Clone, Human;MCP2 cDNA ORF Clone, Human;SCYA10 cDNA ORF Clone, Human;SCYA8 cDNA ORF Clone, Human
MCP2 Background Information

Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP-2), is a small cytokine belonging to the C-C chemokine family. CCL8 functions to activate different immune cells, including mast cells, eosinophils and basophils which are involved in allergic responses, monocytes, and T cells and NK cells which are involved in the inflammatory response. CCL8's ability achieves by binding to different cell surface receptors termed chemokine receptors including CCR1, CCR2B and CCR5. It has been reported that CCL8 is a potent inhibitor of HIV-1 by virtue of its binding to CCR5 which is one of the major co-receptors for HIV-1.

Full Name
chemokine (C-C motif) ligand 8
References
  • Laing KJ, et al. (2004) Chemokines. Developmental and comparative immunology. 28 (5): 443-60.
  • Cocchi F, et al. (1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8+ T cells. Science. 270 (5243): 1811–5.
  • Hori T, et al. (2008) CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease. Blood. 111 (8): 4403-12.
  • Biber K, et al. (2003) Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8. Journal of Leukocyte Biology. 74 (2): 243-51.
  •  

    CCL8/MCP-2 related areas, pathways, and other information

    MCP2 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    MCP2 cDNA ORF Clone in Cloning Vector, Mouse MG50181-M
    MCP2 cDNA ORF Clone, Mouse, untagged MG50181-UT
    MCP2 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50181-ACGLN
    MCP2 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50181-ACG
    MCP2 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50181-ACR
    MCP2 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50181-CF
    MCP2 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50181-NF
    MCP2 cDNA ORF Clone, Mouse, C-His tag MG50181-CH
    MCP2 cDNA ORF Clone, Mouse, N-His tag MG50181-NH
    MCP2 cDNA ORF Clone, Mouse, C-HA tag MG50181-CY
    MCP2 cDNA ORF Clone, Mouse, N-HA tag MG50181-NY
    MCP2 cDNA ORF Clone, Mouse, C-Myc tag MG50181-CM
    MCP2 cDNA ORF Clone, Mouse, N-Myc tag MG50181-NM
    MCP2 qPCR Primer Pairs, Mouse MP200211

    MCP2 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    MCP2 cDNA ORF Clone in Cloning Vector, Human HG10989-M
    MCP2 cDNA ORF Clone, Human, untagged HG10989-UT
    MCP2 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10989-ACGLN
    MCP2 cDNA ORF Clone, Human, C-GFPSpark® tag HG10989-ACG
    MCP2 cDNA ORF Clone, Human, C-OFPSpark® tag HG10989-ACR
    MCP2 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10989-NF
    MCP2 cDNA ORF Clone, Human, C-His tag HG10989-CH
    MCP2 cDNA ORF Clone, Human, N-His tag HG10989-NH
    MCP2 cDNA ORF Clone, Human, C-HA tag HG10989-CY
    MCP2 cDNA ORF Clone, Human, N-HA tag HG10989-NY
    MCP2 cDNA ORF Clone, Human, C-Myc tag HG10989-CM
    MCP2 cDNA ORF Clone, Human, N-Myc tag HG10989-NM
    MCP2 qPCR Primer Pairs, Human HP100952
    info info
    添加购物车成功! 添加购物车失败!