|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|人 Cochlin 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||HG11368-ACG|
|人 Cochlin 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||HG11368-ACR|
|人 Cochlin 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||HG11368-CF|
|人 Cochlin 基因ORF全长cDNA克隆(表达载体), C-His 标签||HG11368-CH|
|人 Cochlin 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||HG11368-CM|
|人 Cochlin 基因ORF全长cDNA克隆(表达载体), C-HA 标签||HG11368-CY|
|人 Cochlin 基因ORF全长cDNA(克隆载体)||HG11368-M|
|人 Cochlin 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||HG11368-NF|
|人 Cochlin 基因ORF全长cDNA克隆(表达载体), N-His 标签||HG11368-NH|
|人 Cochlin 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||HG11368-NM|
|人 Cochlin 基因ORF全长cDNA克隆(表达载体), N-HA 标签||HG11368-NY|
|人 Cochlin 基因ORF全长cDNA克隆(表达载体)||HG11368-UT|
Cochlin, also known as COCH-5B2 and COCH, is a secreted protein which contains one LCCL domain and two VWFA domains. It is an abundant inner ear protein expressed as multiple isoforms. Its function is also unknown, but it is suspected to be an extracellular matrix component. Cochlin and type II collagen are major constituents of the inner ear extracellular matrix, and Cochlin constitutes 70% of non-collagenous protein in the inner ear, the cochlin isoforms can be classified into three subgroups, p63s, p44s and p40s. The expression of cochlin is highly specific to the inner ear. Eleven missense mutation and one in-frame deletion have been reported in the COCH gene, causing hereditary progressive sensorineural hearing loss and vestibular dysfunction, deafness autosomal dominant type 9 (DFNA9). The co-localization of cochlin and type II collagen in the fibrillar substance in the subepithelial area indicate that cochlin may play a role in the structural homeostasis of the vestibule acting in concert with the fibrillar type II collagen bundles. Defects in COCH may contribute to Meniere disease which is an autosomal dominant disorder characterized by hearing loss associated with episodic vertigo.