COMMD9 cDNA ORF Clone, Human, N-DDK (Flag®) tag

Cat: HG14570-NF
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COMMD9 cDNA ORF Clone, Human, N-DDK (Flag®) tag 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
597 bp
描述
Full length Clone DNA of Human COMM domain containing 9 with N terminal Flag tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-N-FLAG
标签序列
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

COMMD9 cDNA ORF Clone, Human, N-DDK (Flag®) tag Alternative Names
HSPC166 cDNA ORF Clone, Human
COMMD9 Background Information

COMMD9 is a COMM domain-containing or COMMD protein. COMMD family is comprised of ten members which are widely conserved throughout evolution and share certain functional properties. They represent a recently discovered set of evolutionarily conserved factors characterized by the presence of a defining carboxy-terminal motif. COMMD protein functions in the control of the transcription factor NFkappaB. NFkappaB plays a critical role in a number of homeostatic processes in multicellular organisms, including the regulation of immunity and cell survival. COMMD proteins inhibit NFkappaB mediated gene expression, and recent mechanistic studies have revealed that COMMD1 controls the ubiquitination of NFkappaB subunits, an event linked to transcriptional termination. COMMD1 binds to a multimeric ubiquitin ligase containing Elongins B/C, Cul2 and SOCS1 (ECS( SOCS1)). In this complex, COMMD1 facilitates the binding of NFkappaB subunits to the ligase, thereby promoting their ubiquitination and degradation. Additional insights gained from these studies indicate that COMMD proteins likely play a broader role in cellular homeostasis through their participation in the ubiquitination pathway.

Full Name
COMM domain containing 9
References
  • Ota T. et al., 2004, Nat Genet. 36 (1): 40-5.
  • Gerhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7.
  • Burstein E. et al., 2005, J Biol Chem. 280 (23): 22222-32.
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    COMMD9 cDNA ORF Clone, Rat, Related Products

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    COMMD9 cDNA ORF Clone, Mouse, Related Products

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    COMMD9 cDNA ORF Clone in Cloning Vector, Mouse MG53852-U
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    COMMD9 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG53852-ACG
    COMMD9 cDNA ORF Clone, Mouse, N-GFPSpark® tag MG53852-ANG
    COMMD9 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG53852-ACR
    COMMD9 cDNA ORF Clone, Mouse, N-OFPSpark® tag MG53852-ANR
    COMMD9 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG53852-CF
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    COMMD9 cDNA ORF Clone, Mouse, C-His tag MG53852-CH
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    COMMD9 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
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    COMMD9 cDNA ORF Clone, Human, N-GFPSpark® tag HG14570-ANG
    COMMD9 cDNA ORF Clone, Human, C-OFPSpark® tag HG14570-ACR
    COMMD9 cDNA ORF Clone, Human, N-OFPSpark® tag HG14570-ANR
    COMMD9 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG14570-CF
    COMMD9 cDNA ORF Clone, Human, C-His tag HG14570-CH
    COMMD9 cDNA ORF Clone, Human, N-His tag HG14570-NH
    COMMD9 cDNA ORF Clone, Human, C-HA tag HG14570-CY
    COMMD9 cDNA ORF Clone, Human, N-HA tag HG14570-NY
    COMMD9 cDNA ORF Clone, Human, C-Myc tag HG14570-CM
    COMMD9 cDNA ORF Clone, Human, N-Myc tag HG14570-NM
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