Dopamine beta-Hydroxylase cDNA ORF Clone, Human, N-HA tag

Cat: HG13440-NY
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Dopamine beta-Hydroxylase cDNA ORF Clone, Human, N-HA tag 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
1812 bp
描述
Full length Clone DNA of Human dopamine beta-hydroxylase (dopamine beta-monooxyge) with N terminal HA tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-N-HA
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Dopamine beta-Hydroxylase cDNA ORF Clone, Human, N-HA tag Alternative Names
DBM cDNA ORF Clone, Human
Dopamine beta-Hydroxylase Background Information

DBH is a 290 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH contains our identical subunits, and its activity requires ascorbate as a cofactor. It functions in in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. DBH has been shown to be associated with decision making and addictive behaviors such as alcohol and smoking, attention deficit hyperactivity disorder, and also with neurological diseases such as Schizophrenia and Alzheimer's.

Full Name
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
References
  • Rush RA. et al., 1980, Crit Rev Clin Lab Sci. 12 (3): 241-77.
  • Goldstein M. et al., 1964, Life Sci. 3 (7): 763-7.
  • S Friedman. et al., 1966, The Journal of Biological Chemistry. 241 (10): 2256-9.
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