Dectin-1 cDNA ORF Clone, Human, C-HA tag

Cat: HG10215-CY

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Dectin-1 cDNA ORF Clone, Human, C-HA tag 基本信息

基因

种属
Human
NCBI 参考序列号
参考序列ORF长度
606 bp
序列描述
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 462C>T not causing the amino acid variation.
描述
Full length Clone DNA of Human C-type lectin domain family 7, member A (CLEC7A), transcript variant 2 with C terminal HA tag.

质粒

启动子
Enhanced CMV promoter
载体
限制性酶切位点
HindIII + XbaI (6kb + 0.65kb)
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

Dectin-1 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Dectin-1 cDNA ORF Clone, Human, C-HA tag Validated Images

Cynomolgus CD19/B4/CVID3 Gene Plasmid Map 5622

Dectin-1 cDNA ORF Clone, Human, C-HA tag Alternative Names

BGR cDNA ORF Clone, Human;CANDF4 cDNA ORF Clone, Human;CLECSF12 cDNA ORF Clone, Human;DECTIN1 cDNA ORF Clone, Human

Dectin-1 Background Information

Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.

Full Name
C-type lectin domain family 7, member A
References
  • Herre J, et al. (2004) The role of Dectin-1 in antifungal immunity. Crit Rev Immunol. 24(3): 193-203.
  • Brown GD. (2006) Dectin-1: a signalling non-TLR pattern-recognition receptor. 6(1): 33-43.
  • Sun L, et al. (2007) The biological role of dectin-1 in immune response. Int Rev Immunol. 26(5-6): 349-64.
  • Schorey JS, et al. (2008) The pattern recognition receptor Dectin-1: from fungi to mycobacteria. Curr Drug Targets. 9(2): 123-9.
  • Reid DM, et al. (2009) Pattern recognition: recent insights from Dectin-1. Curr Opin Immunol. 21(1): 30-7.
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