Desmocollin 2 cDNA ORF Clone, Human, C-His tag

Cat: HG10809-CH

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Desmocollin 2 cDNA ORF Clone, Human, C-His tag 基本信息

基因

种属
Human
NCBI 参考序列号
参考序列ORF长度
2706 bp
描述
Full length Clone DNA of Human desmocollin 2 with C terminal His tag.

质粒

启动子
Enhanced CMV promoter
载体
标签序列
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Desmocollin 2 cDNA ORF Clone, Human, C-His tag Alternative Names

ARVD11 cDNA ORF Clone, Human;CDHF2 cDNA ORF Clone, Human;DG2 cDNA ORF Clone, Human;DGII/III cDNA ORF Clone, Human;DSC3 cDNA ORF Clone, Human

Desmocollin 2 Background Information

DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Like other desmocollins, murine DSC2 has two products, Dsc2a and Dsc2b, produced by alternative splicing of a 46 bp exon which encodes 11 COOH-terminal aa followed by an in-frame stop codon. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in DSC2 are associated with arrhythmogenic right ventricular dysplasia-11. DSC2 is Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms.

Full Name
desmocollin 2
References
  • Nuber UA, et al. (1995) The widespread human desmocollin Dsc2 and tissue-specific patterns of synthesis of various desmocollin subtypes. Eur J Cell Biol. 66 (1): 69-74.
  • Marsden MD, et al. (1997) Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2). Gene. 186 (2): 237-47.
  • Greenwood MD, et al. (1997) Exon-intron organization of the human type 2 desmocollin gene (DSC2): desmocollin gene structure is closer to "classical" cadherins than to desmogleins. Genomics. 44 (3): 330-5.
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    Desmocollin 2 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    Desmocollin 2 cDNA ORF Clone in Cloning Vector, Human HG10809-M
    Desmocollin 2 cDNA ORF Clone, Human, untagged HG10809-UT
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    Desmocollin 2 cDNA ORF Clone, Human, C-GFPSpark® tag HG10809-ACG
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    Desmocollin 2 cDNA ORF Clone, Human, N-Myc tag HG10809-NM
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