Google Search
| 产品数据 | 评论 | 相关产品 | 实验方法 |
Human DKK1 cDNA Clone产品信息
Myc Tag Info
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
人 DKK1/Dkk-1 基因ORF全长cDNA克隆(表达载体), N-Myc 标签 on other vectors
| 点击了解更多载体信息 |
| Product name | Product name |
研究背景
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.
参考资料
Related Products
Contact Us
产品图片
Recommended Products
产品数据可能随批次变化，最新数据请详见随货说明书。
请注意：所有产品都是“仅用于科研，而不能用于诊断或治疗用途”
