ECD cDNA ORF Clone, Human, N-Myc tag

Cat: HG14311-NM
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ECD cDNA ORF Clone, Human, N-Myc tag 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
1935 bp
描述
Full length Clone DNA of Human ecdysoneless homolog (DrosophilA) with N terminal Myc tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-N-Myc
标签序列
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ECD cDNA ORF Clone, Human, N-Myc tag Alternative Names
ECD cDNA ORF Clone, Human;GCR2 cDNA ORF Clone, Human;HSGT1 cDNA ORF Clone, Human
ECD Background Information

ECD, also known as ecdysoneless homolog, belongs to the SGT1 family. It is highly expressed in muscle and heart. ECD is a novel promoter of mammalian cell cycle progression. This function is related to its ability to remove the repressive effects of Rb-family tumor suppressors on E2F transcription factors. It is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells. ECD may also be a transcriptional activator required for the expression of glycolytic genes.

Full Name
ecdysoneless cell cycle regulator
References
  • Badzek S. et al., 2011, Wien Klin Wochenschr. 123 (23-24): 726-31.
  • Zhao X. et al., 2012, Breast Cancer Res Treat. 134 (1): 171-80.
  • Dey P. et al., 2012, Clin Cancer Res. 18 (22): 6188-98.
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