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Enterovirus

Enterovirus 重组蛋白,抗体&基因

Product NameMoleculeCat No.Package/Price 

Product NameApplicationCat No.Package/Price 
Enterovirus 71 VP1 中和抗体MN40013-H136-200
40013-H136-500
200 µg/
500 µg/
Add to Cart
Add to Cart
Enterovirus 71 VP4 中和抗体MN40013-M001-200
40013-M001-500
200 µg/
500 µg/
Add to Cart
Add to Cart

Product NameMoleculeCat No.Package/Price 

Product NameMoleculeCat No.Package/Price 
Product NameMoleculeCat No.Package/Price 

Product NameApplicationCat No.Package/Price 
Enterovirus 71 VP1 中和抗体MN40013-H136-200
40013-H136-500
200 µg/
500 µg/
Add to Cart
Add to Cart
Enterovirus 71 VP4 中和抗体MN40013-M001-200
40013-M001-500
200 µg/
500 µg/
Add to Cart
Add to Cart

Product NameMoleculeCat No.Package/Price 

Product NameMoleculeCat No.Package/Price 

Product NameApplicationCat No.Package/Price 

Product NameMoleculeCat No.Package/Price 

Product NameMoleculeCat No.Package/Price 

What is Enterovirus 71 (EV71)?

Enterovirus 71 (EV71), first isolated in California in 1969, is a member of human enterovirus species A, belongs to genus Enterovirus, family Picornaviridae. It is a small non-enveloped virus with viral particle size about 30 nm in diameter. Infections of enterovirus 71 / EV71 occur mainly in children, and commonly result in mild and self-limiting hand, foot, and mouth disease (HFMD). Read More

Biological Characteristics of Enterovirus 71 (EV71)?

Enterovirus 71 / EV71 is a small non-enveloped virus that contains a positive-sense, single-stranded RNA molecule of approximately 7,400 nucleotides (nt) as its genome. In this RNA molecule, there is a 5'- and 3'- untranslated regions (UTRs) that participate in viral RNA replication; the central area is translated as a single polyprotein, which is then processed into three main cleavage intermediates P1, P2 and P3 by proteolysis. The intermediate P1 can be further cleaved into four structural proteins VP1, VP2, VP3, and VP4 of which the molecular weights are 33 kDa, 28 kDa, 27kDa and 8 kDa, respectively; the intermediate P2 are processed into three nonstructural proteins 2A, 2B and 2C; and the cleavage of intermediate P3 produces four nonstructural proteins 3A, 3B, 3C, and 3D. Read More

Genetic Variations of Enterovirus 71 (EV71)?

The molecular genotyping and epidemiological surveillance of enterovirus 71 / EV71 is conducted by detecting viral VP1. Up to now, three genotypes of enterovirus 71 / EV71 are identified, including genotype A, B and C. Moreover, genotype B can be classified into 5 sub-genotypes, named from B1 to B5; and genotype C also contains 5 sub-genotypes, which are C1 to C5. The outbreak of enterovirus 71 / EV71 appears frequently in the Asia-Pacific region since 1997, and countries such as Malaysia, Singapore, Japan, mainland China, and Taiwan are seriously affected, where sub-genotypes B5 and C4 are found. Read More

Clinical Development of Enterovirus 71 (EV71) Vaccine

Since the infection of enterovirus 71 / EV71 primarily affects countries in the Asia-Pacific region, there is little incentive for vaccine companies from developed countries to develop enterovirus 71 / EV71 vaccines, and mainly the companies and institutes in Asia make efforts to take the vaccines from research to product launch. The ideal candidates for enterovirus 71 / EV71 vaccine should elicit strong cross-genotype neutralizing antibody response and have low costs of the finished products. Candidates based on synthetic peptides, recombinant subunits, virus-like particles, and chemically-inactivated virions are in consideration. Read More

Potential Drug Targets of Enterovirus 71 (EV71)

First, it is a good way to prevent enterovirus 71 / EV71 infection by blocking its entry. Since the VP1 protein contains most of the neutralizing epitopes and acts as a major receptor-binding protein, it is an ideal antiviral target against enterovirus 71 / EV71. Researchers are trying to develop specific antibodies against its neutralizing epitopes. Additionally, due to the important role of VP1 conformational change in viral particle disassembly and RNA release, great efforts are put into designing small molecules that target VP1. Second, proteases 2Apro and 3Cpro are also significant antiviral targets considering their roles in processing viral precursor. Antivirals targeting them should have the ability to inhibit viral protein maturation and prevent host protein from protease degradation as well. Read More

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