FLT4 cDNA ORF Clone, Human, C-DDK (Flag®) tag

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FLT4 cDNA ORF Clone, Human, C-DDK (Flag®) tag: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
4131 bp
序列特征
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 3198C/T not causing the amino acid variation.
产品特征
Full length Clone DNA of Human fms related tyrosine kinase 4.
质粒
启动子
Enhanced CMV promoter
载体
限制性酶切位点
HindIII + XbaI(6kb+4.13kb)
标签序列
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' ) BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

FLT4 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

FLT4 cDNA ORF Clone, Human, C-DDK (Flag®) tag: 验证图片

FLT4 cDNA ORF Clone, Human, C-DDK (Flag®) tag: 别称

FLT-4 cDNA ORF Clone, Human; FLT-41 cDNA ORF Clone, Human; FLT41 cDNA ORF Clone, Human; LMPH1A cDNA ORF Clone, Human; PCL cDNA ORF Clone, Human; VEGF Receptor 3 cDNA ORF Clone, Human; VEGFR-3 cDNA ORF Clone, Human; VEGFR3 cDNA ORF Clone, Human

FLT4 背景信息

Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.
全称
fms related tyrosine kinase 4
参考文献
  • Shushanov S, et al. (2000)VEGFc and VEGFR3 expression in human thyroid pathologies. Int J Cancer.86(1): 47-52.
  • Iljin K, et al. (2001) VEGFR3 gene structure, regulatory region, and sequence polymorphisms. FASEB J. 15(6): 1028-36.
  • Liu XE, et al. (2004) Expression and significance of VEGF-C and FLT-4 in gastric cancer. World J Gastroenterol. 10(3): 352-5.
  • Stearns ME, et al. (2004) Expression of a flt-4 (VEGFR3) splicing variant in primary human prostate tumors. VEGF D and flt-4t(Delta773-1081) overexpression is diagnostic for sentinel lymph node metastasis. Lab Invest. 84(6): 785-95.
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