|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|人 alpha-Galactosidase A 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||HG12078-ACG|
|人 alpha-Galactosidase A 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||HG12078-ACR|
|人 alpha-Galactosidase A 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||HG12078-CF|
|人 alpha-Galactosidase A 基因ORF全长cDNA克隆(表达载体), C-His 标签||HG12078-CH|
|人 alpha-Galactosidase A 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||HG12078-CM|
|人 alpha-Galactosidase A 基因ORF全长cDNA克隆(表达载体), C-HA 标签||HG12078-CY|
|人 alpha-Galactosidase A 基因ORF全长cDNA(克隆载体)||HG12078-G|
|人 alpha-Galactosidase A 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||HG12078-NF|
|人 alpha-Galactosidase A 基因ORF全长cDNA克隆(表达载体), N-His 标签||HG12078-NH|
|人 alpha-Galactosidase A 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||HG12078-NM|
|人 alpha-Galactosidase A 基因ORF全长cDNA克隆(表达载体), N-HA 标签||HG12078-NY|
|人 alpha-Galactosidase A 基因ORF全长cDNA克隆(表达载体)||HG12078-UT|
Alpha-galactosidase A, also known as Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase and GLA, is a member of the glycosyl hydrolase 27 family. GLA is used as a long-term enzyme replacement therapy in patients with a confirmed diagnosis of Fabry disease. Defects in GLA are the cause of Fabry disease (FD) which is a rare X-linked sphingolipidosis disease where glycolipid accumulates in many tissues. The disease consists of an inborn error of glycosphingolipid catabolism. FD patients show systemic accumulation of globotriaoslyceramide (Gb3) and related glycosphingolipids in the plasma and cellular lysosomes throughout the body. Clinical recognition in males results from characteristic skin lesions (angiokeratomas) over the lower trunk. Patients may show ocular deposits, febrile episodes, and burning pain in the extremities. Death results from renal failure, cardiac or cerebral complications of hypertension or other vascular disease. Deficiency of GLA leads to the accumulation of glycosphingolipids in the vasculature leading to multiorgan pathology. In addition to well-described microvascular disease, deficiency of GLA is also characterized by premature macrovascular events such as stroke and possibly myocardial infarction.