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人 HER2 / ErbB2 蛋白

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Human ERBB2 蛋白产品信息
分子别称:CD340,HER-2,HER-2/neu,HER2,MLN 19,MLN19,NEU,NGL,TKR1
蛋白构建:A DNA sequence encoding the human ERBB2 (NP_004439.2) (Met1-Thr652) was expressed with five amino acids (DDDDK) at the C-terminus.
分子种属:Human
表达宿主:Human Cells
运输说明:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human ERBB2 蛋白质控检测
纯度:> 95 % as determined by SDS-PAGE.
内毒素:< 1.0 EU per μg protein as determined by the LAL method.
稳定性:Samples are stable for up to twelve months from date of receipt at -70℃
预测N端:Thr 23
分子量:The recombinant human ERBB2 consists 636 amino acids and predicts a molecular mass of 70 kDa.
缓冲液:Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human ERBB2 蛋白使用指导
储存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶条件:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human ERBB2 蛋白SDS-PAGE
Human HER2 / ErbB2 Protein
Other ERBB2 蛋白 Products
HER2/ErbB2 研究背景

Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Human HER2/ErbB2 参考资料
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
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    货号: 10004-HCCH-50
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    • Human HER2 / ErbB2 Protein
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