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人 B7H7 / HHLA2 基因ORF全长cDNA克隆(表达载体)

  • other Green fluorescent protein / GFP Gene Plasmid Map 5613
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 HHLA2 cDNA Clone产品信息
NCBI注册码:BC035971.1
参考序列ORF长度:1245bp
cDNA基因描述:Full length Clone DNA of Homo sapiens HERV-H LTR-associating 2.
分子别称:B7H7
分子种属:Human
载体:pCMV3-untagged
质粒:pCMV3-HHLA2
限制性酶切位点:KpnI + XbaI(6.1kb+1.25kb)
Tag序列:
序列信息:Identical with the Gene Bank Ref. ID sequence.
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Ampicillin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
Product nameProduct name
研究背景

B7H7 gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants.
HERV–H LTR-associating 2 (HHLA2, also called B7H7/B7-H5/B7y)has been recently discovered as the newest member of the B7 family and has 23–33% similarity in amino acid sequence with the other B7 molecules. This ligand is the only B7 family member that is found in humans but not in mice. It is constitutively expressed on the surface of human monocytes and is induced on B cells. HHLA2 binds to its putative receptor(s) on a variety of immune cells including CD4 and CD8 T cells and antigen-presenting cells. Similarly to B7-H3, both a T cell coinhibitory role as well as a costimulatory role has been reported for this ligand.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

参考资料
  • Janakiram M, Chinai JM, Fineberg S, et al. Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015;21(10):2359-2366.
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    货号: HG16139-UT
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