HRG cDNA ORF Clone, Human, C-HA tag

Cat: HG10836-CY

Contact us:

215-583-7898
order@sinobiological.com
Distributors

All HRG Reagents

CRO Services

Product recommended


All HRG Reagents

HRG cDNA ORF Clone, Human, C-HA tag 基本信息

基因

种属
Human
NCBI 参考序列号
参考序列ORF长度
1578 bp
描述
Full length Clone DNA of Human histidine-rich glycoprotein with C terminal HA tag.

质粒

启动子
Enhanced CMV promoter
载体
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

HRG cDNA ORF Clone, Human, C-HA tag Alternative Names

HPRG cDNA ORF Clone, Human;HRGP cDNA ORF Clone, Human;THPH11 cDNA ORF Clone, Human

HRG Background Information

Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets, and contains an unusually large amount of histidine and proline. In human, five distinct domains are recognized in the mature HPRG molecule. There are two N-terminal cystatin-like modules (aa 19 - 254) and one His-Pro-rich region (aa 350 - 497) that is flanked by two Pro-rich segments (aa 276 - 321 and 498 - 525). The His-Pro-rich region contains 10 tandem repeats with an HHPHG motif, and the N- and C-termini are linked by a disulfide bond. The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells.

Full Name
histidine-rich glycoprotein
References
  • Guan X, et al. (2004) Histidine-proline rich glycoprotein (HPRG) binds and transduces anti-angiogenic signals through cell surface tropomyosin on endothelial cells. Thromb Haemost. 92(2): 403-12.
  • Doate F, et al. (2004) Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities. Cancer Res. 64(16): 5812-7.
  • HRG cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    HRG cDNA ORF Clone in Cloning Vector, Rat RG81643-G
    HRG cDNA ORF Clone, Rat, untagged RG81643-UT
    HRG Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG81643-ACGLN
    HRG cDNA ORF Clone, Rat, C-GFPSpark® tag RG81643-ACG
    HRG cDNA ORF Clone, Rat, N-GFPSpark® tag RG81643-ANG
    HRG cDNA ORF Clone, Rat, C-OFPSpark® tag RG81643-ACR
    HRG cDNA ORF Clone, Rat, N-OFPSpark® tag RG81643-ANR
    HRG cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG81643-CF
    HRG cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG81643-NF
    HRG cDNA ORF Clone, Rat, C-His tag RG81643-CH
    HRG cDNA ORF Clone, Rat, N-His tag RG81643-NH
    HRG cDNA ORF Clone, Rat, C-HA tag RG81643-CY
    HRG cDNA ORF Clone, Rat, N-HA tag RG81643-NY
    HRG cDNA ORF Clone, Rat, C-Myc tag RG81643-CM
    HRG cDNA ORF Clone, Rat, N-Myc tag RG81643-NM

    HRG cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    HRG cDNA ORF Clone in Cloning Vector, Human HG10836-M
    HRG cDNA ORF Clone, Human, untagged HG10836-UT
    HRG Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10836-ACGLN
    HRG cDNA ORF Clone, Human, C-GFPSpark® tag HG10836-ACG
    HRG cDNA ORF Clone, Human, C-OFPSpark® tag HG10836-ACR
    HRG cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10836-CF
    HRG cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10836-NF
    HRG cDNA ORF Clone, Human, C-His tag HG10836-CH
    HRG cDNA ORF Clone, Human, N-His tag HG10836-NH
    HRG cDNA ORF Clone, Human, N-HA tag HG10836-NY
    HRG cDNA ORF Clone, Human, C-Myc tag HG10836-CM
    HRG cDNA ORF Clone, Human, N-Myc tag HG10836-NM
    HRG qPCR Primer Pairs, Human HP100735
    info info
    添加购物车成功! 添加购物车失败!