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人 IGF-1 / IGF-I / IGF1 蛋白

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Human IGF1 蛋白产品信息
分子别称:IGF-1,IGF-I,IGF1A,IGFI,IGF‑I,MGF
蛋白构建:A DNA sequence encoding the human IGF1 (NP_001104754.1) (Gly49-Ala118) was expressed.
分子种属:Human
表达宿主:Yeast
运输说明:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human IGF1 蛋白质控检测
纯度:> 95 % as determined by SDS-PAGE
生物活性:Measured in a cell proliferation assay using MCF-7 cells. The ED50 for this effect is 9-36 ng/mL.
内毒素:Please contact us for more information.
稳定性:Samples are stable for up to twelve months from date of receipt at -70℃
预测N端:Gly 49
分子量:The recombinant human IGF1 consists 70 amino acids and predicts a molecular mass of 7.7 kDa.
缓冲液:Lyophilized from sterile PBS,pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human IGF1 蛋白使用指导
储存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶条件:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human IGF1 蛋白SDS-PAGE
Human IGF-1 / IGF-I / IGF1 Protein

IGF1 相关信号通路

    Other IGF1 蛋白 Products
    IGF1/IGF‑I/IGF-1 研究背景

    IGF I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.

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    货号: 10598-HNAY-100
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    • Human IGF-1 / IGF-I / IGF1 Protein
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